Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Background: Sepsis is the commonest cause of neonatal mortality in developing countries. Routinely available markers of risk such as birth weight and gestational age do not adequately capture the dimension of illness severity and so, many sepsis scoring systems were developed. Score for neonatal acute physiology II (SNAP II) and its perinatal extension (SNAPPE II) were originally developed to predict the risk of dying at admission to neonatal intensive care units (NICUs). It is also used to predict organ dysfunction in neonates with septicemia. Objectives: The present study was done to assess the efficiency of SNAP II/SNAPPE II score as a tool to predict the risk for neonatal mortality and organ dysfunction in Neonates with septicemia in NICUs. Study also aimed for early anticipation of clinical manifestations of sepsis which will correlate most with poor outcome and so, determine appropriate time to give specific treatment. Patient and method: This is observational prospective study which includes neonates with septicemia admitted to NICUs at Elgalaa Children{u2019}s military hospital and Children{u2019}s hospital, Cairo university within the period of september 2017 till August 2018. It included neonates (preterm and fullterm) of both genders. Study included 2 groups, each of them 50 neonates with septicemia (total 100 neonates). One group of premature neonates (32-36 weeks), the other group of fullterm neonates (37-41 weeks). Neonates either had sepsis or severe sepsis. All included patients were subjected to full history taking, clinical assessment and investigations. SNAP II / SNAPPE II were done for all included neonates within 24 hours of sepsis onset with follow up of these neonates for mortality and organ dysfunction for 14 days

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