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Ultrastructural morphological study of in-vitro 3D cultured hepatocytes / Ehab Osama Ahmed Hafiz ; Supervised Ali Ahmed Fouad Elhindawi , Soheir Saiid Mansy , Martin L. Yarmush

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ehab Osama Ahmed Hafiz , 2019Description: 149 P. : facsimiles ; 25cmOther title:
  • دراسة التغيرات فى التركيب الدقيق للخلايا الكبدية المزروعة بتقنية ثلاثية الأبعاد [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology Summary: End stage liver disease faces a global problem of severe shortage of high-quality donor organs as orthotopic liver transplantation is the only current treatment method. Tissue engineering aims to create transplantable liver grafts that can serve as substitutes for donor livers or bridge patients till transplantation. Current approaches in liver tissue engineering have yet to address the biliary component of the organ and hence fail to deliver a three-dimensional (3D) model that correctly mimics the native liver architecture. Biliary component of the liver architecture is composed of cholangiocytes that line the biliary ductules and are responsible for transporting and modifying the bile produced by hepatocytes. The major challenge in recreating the biliary drainage in an engineered construct has been the integration of bile canaliculi with the biliary ductular network and allowing the clearance of bile from the hepatocytes to the host duodenum
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.Ph.D.2019.Eh.U (Browse shelf(Opens below)) Not for loan 01010110078951000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.Ph.D.2019.Eh.U (Browse shelf(Opens below)) 78951.CD Not for loan 01020110078951000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology

End stage liver disease faces a global problem of severe shortage of high-quality donor organs as orthotopic liver transplantation is the only current treatment method. Tissue engineering aims to create transplantable liver grafts that can serve as substitutes for donor livers or bridge patients till transplantation. Current approaches in liver tissue engineering have yet to address the biliary component of the organ and hence fail to deliver a three-dimensional (3D) model that correctly mimics the native liver architecture. Biliary component of the liver architecture is composed of cholangiocytes that line the biliary ductules and are responsible for transporting and modifying the bile produced by hepatocytes. The major challenge in recreating the biliary drainage in an engineered construct has been the integration of bile canaliculi with the biliary ductular network and allowing the clearance of bile from the hepatocytes to the host duodenum

Issued also as CD

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