Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy

Clerodendrum inerme L. gaertn. and clerodendrum splendens G. Don, two members of the cosmopolitan family Lamiaceae, are successfully acclimatized in Egypt. The current study aimed to evaluate the local plants as potential candidates for implementation in pharmaceutical industries, which necessitates an intensive investigation of safety and bioactivity of the cited species. To ensure quality and purity of the raw material, criteria for characterization of and/or discrimination between the two species were established via botanical profiling, proximate analysis, phytochemical screening and UPLC analysis. The leaves were subjected to comparative biological and chemical study to select the most suitable from the medicinal and economic standpoints. In this respect, the antioxidant cyotoxic and antimicrobial potentials of the defatted ethanol (70%) extracts of the tested samples were assessed in-vitro. Meanwhile, the chemical composition of the leaves was examined through qualitative and quantitative comparative analyses of the phenolic components. In this respect, The leaves of C. inerme were selected for more intensive both phytochemical and biological investigation

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