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Elevated NT-pro BNP plasma level as a marker of acute and sub-acute ventricular affection in breast cancer patients receiving chemotherapy / Laila Sulaiman Saleh Bashuqair ; Supervised Magdy Abdelhamid , Ghada Sayed Mahmoud , Dina Hesham Ahmed Soliman

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Laila Sulaiman Saleh Bashuqair , 2019Description: 107 P. : charts , facsimiles ; 25cmOther title:
  • في البلازما كمؤشر لتأثر البطين الحاد و تحت الحاد في مريضات سرطان الثدي اللاتي يأخدنا علاجا كيميائيا ( NT-pro BNP )ارتفاع هرمون [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Cardiology Summary: Background: Chemotherapeutic agents used for treatment of breast cancer have many side effects, among them is cardiomyopathy. Despite that ejection fraction (EF) is a widely accepted echocardiographic method, yet it fails to detect subtle alterations of LV function. There comes a need for a more sensitive tool for detection of preclinical chemotherapy-induced cardiomyopathy. Purpose: Detection of preclinical LV systolic and/or diastolic dysfunction, using NT-BNP plasma level in breast cancer patients within 6 weeks after the initiation of their chemotherapeutic treatment. Methods: Seventy-four non-metastasizing breast cancer female patients with no cardiovascular risk factors were included. They were assessed right before taking their first chemotherapeutic session and 6 weeks thereafter. Assessment included age, two-dimensional (2D) as well as three-dimensional (3D) echocardiography. Blood samples for NT-BNP plasma level were collected before and 6 weeks after the initiation of chemotherapy. Samples were later analyzed using a Sandwich ELISA technique
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.04.M.Sc.2019.La.E (Browse shelf(Opens below)) Not for loan 01010110079221000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.04.M.Sc.2019.La.E (Browse shelf(Opens below)) 79221.CD Not for loan 01020110079221000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Cardiology

Background: Chemotherapeutic agents used for treatment of breast cancer have many side effects, among them is cardiomyopathy. Despite that ejection fraction (EF) is a widely accepted echocardiographic method, yet it fails to detect subtle alterations of LV function. There comes a need for a more sensitive tool for detection of preclinical chemotherapy-induced cardiomyopathy. Purpose: Detection of preclinical LV systolic and/or diastolic dysfunction, using NT-BNP plasma level in breast cancer patients within 6 weeks after the initiation of their chemotherapeutic treatment. Methods: Seventy-four non-metastasizing breast cancer female patients with no cardiovascular risk factors were included. They were assessed right before taking their first chemotherapeutic session and 6 weeks thereafter. Assessment included age, two-dimensional (2D) as well as three-dimensional (3D) echocardiography. Blood samples for NT-BNP plasma level were collected before and 6 weeks after the initiation of chemotherapy. Samples were later analyzed using a Sandwich ELISA technique

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