header
Image from OpenLibrary

Genetic and immunomodulatory profiling of Egyptian breast cancer patients using next generation sequencing and its possible correlation to viral infection / Auhood Abdelmonem Ali Nassar ; Supervised Abdelrahman Zekri , Samah Ali Lotfy , Othman Mansour

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Auhood Abdelmonem Ali Nassar , 2019Description: 144 P. : charts ; 25cmOther title:
  • النمط الجيني والمناع{u٠٦أأ} للمرضى المصريين المصابين بسرطان الثدي باستخدام تكنولوجيا الجيل القادم لتسلسل الاحماض الامينية ومدى علاقته بالعدوى الفيروسية [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Cancer Biology Summary: Breast cancer is the leading cause of cancer-related death in women worldwide. In Egypt, its incidence is progressively increasing with a great tendency to occur with advanced stages in younger ages. Based on biological characteristics and on gene expression pattern, it was classified into different subtypes each exhibits a unique gene mutation profile. Therefore, research is needed to investigate the unknown genetic mutations involved in the progression of that disease. This study aimed to sequence 409 exons of tumor suppressor genes and oncogenes to identify the frequency of the detected genetic mutations in Egyptian breast cancer patients using Ion Comprehensive Cancer Panel. Forty-eight tissue samples of various breast cancer subtypes and five fibroadenoma samples were collected from National Cancer Institute (NCI), Cairo University. The detected genetic variants were annotated against 1000 genomes and dbSNP reference databases. Also, the Egyptian genome variation data were used to filter out Egyptian-specific normal polymorphism. Analysis revealed 191 exonic and splicing variants
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.02.Ph.D.2019.Au.G (Browse shelf(Opens below)) Not for loan 01010110079249000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.02.Ph.D.2019.Au.G (Browse shelf(Opens below)) 79249.CD Not for loan 01020110079249000

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Cancer Biology

Breast cancer is the leading cause of cancer-related death in women worldwide. In Egypt, its incidence is progressively increasing with a great tendency to occur with advanced stages in younger ages. Based on biological characteristics and on gene expression pattern, it was classified into different subtypes each exhibits a unique gene mutation profile. Therefore, research is needed to investigate the unknown genetic mutations involved in the progression of that disease. This study aimed to sequence 409 exons of tumor suppressor genes and oncogenes to identify the frequency of the detected genetic mutations in Egyptian breast cancer patients using Ion Comprehensive Cancer Panel. Forty-eight tissue samples of various breast cancer subtypes and five fibroadenoma samples were collected from National Cancer Institute (NCI), Cairo University. The detected genetic variants were annotated against 1000 genomes and dbSNP reference databases. Also, the Egyptian genome variation data were used to filter out Egyptian-specific normal polymorphism. Analysis revealed 191 exonic and splicing variants

Issued also as CD

There are no comments on this title.

to post a comment.