Association of pentraxin 3 with atherosclerosis in patients with type 2 diabetes / Radwa Bakry Mohammad ; Supervised Nehal Hamdy Elsaid , Naglaa Mohamed Elsayed , Nagwa Abdelghaffar Mohamed

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

Background:Type 2 diabetes mellitus is a major health problem that is rising with time.Type 2 diabetes mellitus lead to several complications including cardiovascular diseases. Cardiovascular disease is a main cause of death globally. Both of inflammatory factors and immune response are involved in atherosclerosis development. Pentraxin is a reactant of acute phase which shares functional and structural homology with CRP. Pentraxin concentration rises after episodes such as acute myocardial infarction.Objective:To evaluate the association between pentraxin 3 and atherosclerosis disease in type 2 diabetes mellitus patients.Patients and Method:This is a case control study that included 3 groups, the first group included patients with type 2 diabetes mellitus and known cardiovascular complication, the second group included type2 diabetes mellitus patients without complications and the third group included healthy individuals. Clinical examination and laboratory investigation were performed for all participants as well as pentraxin 3.Results: By comparing the results of the three groups, there were significant differences between the three groups regarding each of SBP, DBP, FBS, 2Hr PP and HbA1c where P-value {u02C2}0.001 for each, also there were significant differences regarding AST (P=0.02), creatinine (P=0.01), creatinineclearance (P=0.008), pentraxin (P {u02C2}0.001)and carotid intima media thickness (P{u02C2}0.001). In diabetic group with complication, pentraxin was found to change with carotid intima media thickness (Ý=67.466, P{u02C2}0.001).Conclusion: Pentraxin is associated with atherosclerosis in patients with type 2 diabetes mellitus

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