A comparative histological and immunohistochemical study on the effect of metformin versus selenium on testicular ischemia/reperfusion injury in adult albino rats / Noura Mostafa Kamel ; Supervised Abeer Fouad Abdelmohsen , Dina Mohamed Radwan , Marwa Mohamed Yousry

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Noura Mostafa Kamel

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TextLanguage: English Publication details: Cairo : Noura Mostafa Kamel , 2019Description: 120 P. : charts , facsimiles ; 25cmOther title:

دراسة هستولوجية وهستوكيميائية مناعية مقارنة على تأثير الميتفورمين مقابل السيلينيوم على إصابة الخصية من نقص التروية و إعادة الإشباع في الجرذان البيضاء البالغة [Added title page title]

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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Histology Summary: Background and objectives:Testicular torsion is an emergency condition that requires urgent surgical detorsion to avoid testicular necrosis. This study was designed to evaluate and compare the possible effects of metformin versus selenium on testicularischemia/reperfusion(I/R) injury in a rat model. Materials and Methods: Forty-eight adult male albino rats were used in this study, 16 rats served as sham-operated control (I), the remaining 32 rats divided equally into 4 groups: (II) ischemic, (III)I/R, (IV) I/R+ Metformin and (V) I/R+ Selenium. GIIwas subjected to 1-hour of ischemia then sacrificed. GIIIwas subjected to 1-hour of ischemia and 7 days of reperfusion then sacrificed. GIV and GVwere subjected to I/R injury, GIV received 100 mg/kg/day of metformin by oral gavage and GV received an intraperitoneal injection of 0.5 mg/kg/day of selenium, for 7 consecutive days then sacrificed. Just before sacrifice, blood samples were drawn and serum levels of malondialdehyde(MDA), glutathione(GSH)and testosterone were measured. Left testicular sections were stained with H&E, PAS and immunohistochemical stains for caspase-3 and connexin43 (CX43).Morphometric and statistical studieswere done

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Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.16.M.Sc.2019.No.C (Browse shelf(Opens below))		Not for loan		01010110079901000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.16.M.Sc.2019.No.C (Browse shelf(Opens below))	79901.CD	Not for loan		01020110079901000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Histology

Background and objectives:Testicular torsion is an emergency condition that requires urgent surgical detorsion to avoid testicular necrosis. This study was designed to evaluate and compare the possible effects of metformin versus selenium on testicularischemia/reperfusion(I/R) injury in a rat model. Materials and Methods: Forty-eight adult male albino rats were used in this study, 16 rats served as sham-operated control (I), the remaining 32 rats divided equally into 4 groups: (II) ischemic, (III)I/R, (IV) I/R+ Metformin and (V) I/R+ Selenium. GIIwas subjected to 1-hour of ischemia then sacrificed. GIIIwas subjected to 1-hour of ischemia and 7 days of reperfusion then sacrificed. GIV and GVwere subjected to I/R injury, GIV received 100 mg/kg/day of metformin by oral gavage and GV received an intraperitoneal injection of 0.5 mg/kg/day of selenium, for 7 consecutive days then sacrificed. Just before sacrifice, blood samples were drawn and serum levels of malondialdehyde(MDA), glutathione(GSH)and testosterone were measured. Left testicular sections were stained with H&E, PAS and immunohistochemical stains for caspase-3 and connexin43 (CX43).Morphometric and statistical studieswere done

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