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Role of NHERF1 gene expression and serum FGF-23 in phosphate homeostasis among renal transplanted patients / Emily Samir Mikhael Georgy ; Supervised Mohamed Shehata Abdalla , Dina Hesham Ahmed , Mai Hamed Mohamed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Emily Samir Mikhael Georgy , 2019Description: 121 P. : charts , facsimiles ; 25cmOther title:
  • فى المصل فى توازن الفوسفات بين مرضى زراعة الكلي FGF-23 و مستوى ال NHERF1 دور التعبير الجينى ل [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Background: Chronic kidney disease (CKD) is considered a major health problem with dysregulated phosphate metabolism as a common consequence. Fibroblast Growth Factor -23 (FGF-23) is a hormone, whose major function is to inhibit renal tubular phosphate reabsorption.The Sodium/Hydrogen exchanger regulatory factor-1 (NHERF1)is a scaffolding protein that isimportant in the regulation of protein trafficking,where it increases the abundance of the main renal phosphate transporter (NaPi-IIa) in the apical membrane of proximal tubular cells. Aim of work: The aim of the present study is to investigate the clinical relevance of NHERF1 geneexpression in peripheral blood as well as FGF-23 serum level in patients with end stage renal disease before and 6 months after renal transplantation and their probable association with phosphate level. Subjects and Methods:The present study was carried out prospectively on 37 consecutive adult patientswith end stage renal disease who underwent renal transplantationin which patients of the study were as follow:Patients before transplantation: including 37 patients with end stage renal disease before transplantation. Patients after transplantation: including same patients 6 months afterdoing renal transplantation. FGF-23 serum level was measured using Enzyme Linked Immunosorbent Assay. NHERF1 gene expression was determined by Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR)
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2019.Em.R (Browse shelf(Opens below)) Not for loan 01010110079902000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2019.Em.R (Browse shelf(Opens below)) 79902.CD Not for loan 01020110079902000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Background: Chronic kidney disease (CKD) is considered a major health problem with dysregulated phosphate metabolism as a common consequence. Fibroblast Growth Factor -23 (FGF-23) is a hormone, whose major function is to inhibit renal tubular phosphate reabsorption.The Sodium/Hydrogen exchanger regulatory factor-1 (NHERF1)is a scaffolding protein that isimportant in the regulation of protein trafficking,where it increases the abundance of the main renal phosphate transporter (NaPi-IIa) in the apical membrane of proximal tubular cells. Aim of work: The aim of the present study is to investigate the clinical relevance of NHERF1 geneexpression in peripheral blood as well as FGF-23 serum level in patients with end stage renal disease before and 6 months after renal transplantation and their probable association with phosphate level. Subjects and Methods:The present study was carried out prospectively on 37 consecutive adult patientswith end stage renal disease who underwent renal transplantationin which patients of the study were as follow:Patients before transplantation: including 37 patients with end stage renal disease before transplantation. Patients after transplantation: including same patients 6 months afterdoing renal transplantation. FGF-23 serum level was measured using Enzyme Linked Immunosorbent Assay. NHERF1 gene expression was determined by Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR)

Issued also as CD

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