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Effect of cisplatin on cerebellum of albino rat and possible protective role of granulocyte colony stimulating factor versus citrullus lanatus juice : A histological study / Shaimaa Mohammed Zaki Zaher ; Supervised Abeer Fouad Abdelmohsen , Nagwa Abdelwahab Ahmed , Zainab Mohammed Altayeb Ahmad

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Shaimaa Mohammed Zaki Zaher , 2019Description: 220 P. : charts , facsimiles ; 25cmOther title:
  • تأثير السيسبلاتين على مخيخ الجرذ الأبيض و الدور الوقائى المحتمل للعامل المحفز لمستعمرات الخلايا المحببة ضد عصير السيترولوس لاناتوس : دراسة هستولوجية [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Histology Summary: The purpose of this study was to examine the effect of cisplatin on histological structure of cerebellum and possible protective role of granulocyte colony stimulating factor (G-CSF) versus citrullus lanatus juice. Forty adult male albino rats were divided into control group, group I: rats received cisplatin by intraperitoneal (IP) injection at a dose of 10 mg/kg on days 6 and 13, group II: rats received G-CSF by subcutaneous (SC) injection at a dose of 50 æg /kg for 5 consecutive days then cisplatin on days 6 and 13 and group III: rats received citrullus lanatus juice daily (for 16 days) by oral gavage at a dose of 4ml/kg in concomitant with cisplatin on days 6 and 13. Blood samples were taken to measure plasma malondialdehyde (MDA) and reduced glutathione (GSH) levels. Cerebellar biopsies were processed for light microscopy using H&E, Bielschowsky silver and immunohistochemical stains (glial fibrillary acidic protein (GFAP) & caspase-3) as well as for electron microscopy. Morphometric and statistical studies were done for mean number of Purkinje cells, mean thickness of granular layer, mean area percent of GFAP positive cells and mean optical density of caspase-3 positive cells
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.16.Ph.D.2019.Sh.E (Browse shelf(Opens below)) Not for loan 01010110079966000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.16.Ph.D.2019.Sh.E (Browse shelf(Opens below)) 79966.CD Not for loan 01020110079966000
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Cai01.11.16.Ph.D.2019.Em.P The possible neuroprotective effect of astaxanthin on monosodium glutamate and aspartame induced brain changes in albino rats / Cai01.11.16.Ph.D.2019.Em.P The possible neuroprotective effect of astaxanthin on monosodium glutamate and aspartame induced brain changes in albino rats / Cai01.11.16.Ph.D.2019.Sh.E Effect of cisplatin on cerebellum of albino rat and possible protective role of granulocyte colony stimulating factor versus citrullus lanatus juice : A histological study / Cai01.11.16.Ph.D.2019.Sh.E Effect of cisplatin on cerebellum of albino rat and possible protective role of granulocyte colony stimulating factor versus citrullus lanatus juice : A histological study / Cai01.11.16.Ph.D.2022.Ay.H Histological Study on The Effect of Mesenchymal Stem Cells Versus Exosomes on Chemically Induced Liver Injury in Adult Male Albino Rats / Cai01.11.16.Ph.D.2022.Em.c Comparative histological and immunohistochemical study on the therapeutic efficacy of platelet-rich plasma, adipose tissue derived mesenchymal stem cells and mesenchymal stem cells derived exosomes in experimentally induced corneal alkali burn in rats / Cai01.11.16.Ph.D.2022.Ka.P Protective role of fenugreek saponin nanoparticles against genotoxicity and histopathological alterations induced by nicotine in male rats /

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Histology

The purpose of this study was to examine the effect of cisplatin on histological structure of cerebellum and possible protective role of granulocyte colony stimulating factor (G-CSF) versus citrullus lanatus juice. Forty adult male albino rats were divided into control group, group I: rats received cisplatin by intraperitoneal (IP) injection at a dose of 10 mg/kg on days 6 and 13, group II: rats received G-CSF by subcutaneous (SC) injection at a dose of 50 æg /kg for 5 consecutive days then cisplatin on days 6 and 13 and group III: rats received citrullus lanatus juice daily (for 16 days) by oral gavage at a dose of 4ml/kg in concomitant with cisplatin on days 6 and 13. Blood samples were taken to measure plasma malondialdehyde (MDA) and reduced glutathione (GSH) levels. Cerebellar biopsies were processed for light microscopy using H&E, Bielschowsky silver and immunohistochemical stains (glial fibrillary acidic protein (GFAP) & caspase-3) as well as for electron microscopy. Morphometric and statistical studies were done for mean number of Purkinje cells, mean thickness of granular layer, mean area percent of GFAP positive cells and mean optical density of caspase-3 positive cells

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