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A pharmaceutical study on a sparingly soluble drug / Fady Adel Malaak ; Supervised Mohamed Ahmed Elnabarawi , Shahinaze Amry Aly Fouad

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Fady Adel Malaak , 2019Description: 257 P. : charts , facsimiles ; 25cmOther title:
  • دراسة صيدلية على أحد العقاقير الشحيحة الذوبان [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: Enhancement of solubility, dissolution rate and bioavailability is a challenging mission in drug development, more than 70% of the new chemical entities currently being discovered are poorly water soluble drugs. Aqueous solubility of any therapeutically active substance is a key properly as it governs dissolution, absorption and thus the in vivo efficacy. Diacerein (DCN) used in the treatment of osteoarthritis (OA). DCN is an anthraquinone derivative that has been shown to inhibit the production of interleukin-1 (IL-1) and reduce cartilage breakdown and the development of cartilage lesions in preclinical models of OA. DCN has a history of low bioavailability (35%-56%) which is attributed to poor dissolution. Over the last few years, various approaches aimed to enhance DCN solubility include complexation and solid lipid nanoparticles. The aim of work in this thesis is to increase the solubility and bioavailability using DCN as a model of poorly water soluble drug and form a novel formulation as orodispersible tablet (ODT)
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2019.Fa.P (Browse shelf(Opens below)) Not for loan 01010110080096000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2019.Fa.P (Browse shelf(Opens below)) 80096.CD Not for loan 01020110080096000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Enhancement of solubility, dissolution rate and bioavailability is a challenging mission in drug development, more than 70% of the new chemical entities currently being discovered are poorly water soluble drugs. Aqueous solubility of any therapeutically active substance is a key properly as it governs dissolution, absorption and thus the in vivo efficacy. Diacerein (DCN) used in the treatment of osteoarthritis (OA). DCN is an anthraquinone derivative that has been shown to inhibit the production of interleukin-1 (IL-1) and reduce cartilage breakdown and the development of cartilage lesions in preclinical models of OA. DCN has a history of low bioavailability (35%-56%) which is attributed to poor dissolution. Over the last few years, various approaches aimed to enhance DCN solubility include complexation and solid lipid nanoparticles. The aim of work in this thesis is to increase the solubility and bioavailability using DCN as a model of poorly water soluble drug and form a novel formulation as orodispersible tablet (ODT)

Issued also as CD

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