Epidemiological profile of inflammatory bowel disease among patients attending national hepatology and tropical medicine research institute / Rahma Mohammed Medhat Ali ; Supervised Eman Taher Elsayed , Kamal Eldeen Abdelrahman Elatrebi , Fayrouz Hamed Elaguizy

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Community Medicine

Background: Inflammatory bowel disease IBD, comprising Crohn's disease and ulcerative colitis, was previously considered 'low risk' in developing countries as the Middle East and North Africa, which are witnessing an evident increase in incidence. Aim: this study aimed at evaluating the pattern of IBD in patients attending NHTMRI, and studying possible risk factors. Methods: A case {u2013} control analytical study. A pre-tested questionnaire was directed to 200 outpatients at NHTMRI and 200 controls through a period of almost 1 year. Results: Out of 200 cases, 176 had UC, and 24 had CD. Most of them were females 56%.Median and IQR agewere 36(17) vs.31 (13) respectively, (p=0.03).Cases smoked for longer durations than controls (p=0.000). CD cases had history of tonsillectomy more than UC patients (p=0.01). Cases consumed less vegetables (p=0.001, 0.751, 0.000, 0.009), and dairy products (p=0.004, 0.001, 0.000). While they consumed more fats (p=0.001, 0.000), proteins (p=0.000, 0.000, 0.004, 0.001, 0.000, 0.000), carbohydrates (p=0.000, 0.003, 0.000) and carbonated drinks (p=0.000). Most UC cases had left sided lesions (n=96), and were of moderate disease activity (52.2%). Most CD cases had ileitis (n=9)and suffered from moderate disease activity (60%).Peripheral arthropathy was the most common extraintestinal manifestation (70%).Biological treatments were taken by 15.4% of UC patients, and 20.8% of CD patients. Quality of life was significantly affected by this illness (p=0.00)

Issued also as CD