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Expression of 2L1CAM3 in endometrial carcinomas : Histopathological and immunohistochemical study / Aya Magdy Elsayed Elyamany ; Supervised Solafa Amin Abdelaziz , Samar Abdelmonem Elsheikh , Somia Abdulatif Mahmoud Soliman

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Aya Magdy Elsayed Elyamany , 2019Description: 129 P. : charts , facsimiles ; 25cmOther title:
  • التعبير عن " إل1 كام" فى أورام بطانة الرحم : دراسة هستوباثولوجية وهستوكيميائية مناعية [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology Summary: Background: Endometrial cancer is the most common cancer of the female genital tract. No effective biomarkers currently exist to allow for an efficient risk classification of endometrial carcinoma or to direct treatment (adjuvant radiation and/or chemotherapy), or to triage pelvic and para-aortic lymphadenectomy. L1CAM a transmembrane protein of the immunoglobulin family that has been implicated in promoting tumor cell proliferation, migration, invasion, and metastasis became an attractive candidate as a potential biomarker in endometrial carcinoma and potential therapeutic target in high risk groups. Objectives: Evaluation of L1CAM expression in endometrial carcinoma and correlation of this expression with various pathological parameters. Material and methods: Immunohistochemical staining for L1CAM was performed on paraffin-embedded sections of 80 cases of endometrial carcinomas that underwent total hysterectomy with bilateral salpingo-oophorectomy. Expression of L1CAM in >10% of tumor cells was described as positive
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.Ph.D.2019.Ay.E (Browse shelf(Opens below)) Not for loan 01010110080174000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.Ph.D.2019.Ay.E (Browse shelf(Opens below)) 80174.CD Not for loan 01020110080174000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology

Background: Endometrial cancer is the most common cancer of the female genital tract. No effective biomarkers currently exist to allow for an efficient risk classification of endometrial carcinoma or to direct treatment (adjuvant radiation and/or chemotherapy), or to triage pelvic and para-aortic lymphadenectomy. L1CAM a transmembrane protein of the immunoglobulin family that has been implicated in promoting tumor cell proliferation, migration, invasion, and metastasis became an attractive candidate as a potential biomarker in endometrial carcinoma and potential therapeutic target in high risk groups. Objectives: Evaluation of L1CAM expression in endometrial carcinoma and correlation of this expression with various pathological parameters. Material and methods: Immunohistochemical staining for L1CAM was performed on paraffin-embedded sections of 80 cases of endometrial carcinomas that underwent total hysterectomy with bilateral salpingo-oophorectomy. Expression of L1CAM in >10% of tumor cells was described as positive

Issued also as CD

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