Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Various hepatic and biliary disorders could be met within neonatal intensive care units. They should be detected early and evaluated promptly. Aim: Determination of the frequency, causes and short term outcome in neonates with hepatobiliary dysfunction admitted to neonatal Intensive Care Unit (NICU). Methods: This observational descriptive cross-sectional study was conducted at El Monira children{u2019}s hospital NICU, Cairo University between January and December 2018. Results: Hepatobiliary dysfunction occurred in 43 cases and represented 4.1% of the total admissions during the period of the study. Hepatobiliary dysfunctions were in form of cholestasis, elevated liver enzymes or hepatomegly. Cholestasis was the most frequent form of liver affection where it was present in 81.3% of cases. Elevated liver enzymes and hepatomegly were present in 49% (21 patients) and 25.6 % (11 patients) respectively. The main causes of hepatobiliary dysfunctions included: inspissated bile syndrome secondary to hemolytic anemia (n=24, 55.8%), ischemia/hypoxia (n=14, 32.6%), sepsis (n=12, 28%), biliary atresia (n=2, 4.7%), passive congestion 2ry to heart failure (n=1, 2.3%) and congenital adrenal hyperplasia (n=1, 2.3%). The exact cause not completely determined in 3 patients (7.0% of our cases)

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