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Expression of O⁶-methylguanine dna methyltransferase (MGMT) in colorectal cancer : Immunohistochemical and histopathological study / Mohamed Ahmed Ahmed Hussien ; Supervised Badawia Bayoumi Ibrahim , Samira Abdalah Mahmoud , Maya Mohammed Hamza Elserafy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohamed Ahmed Ahmed Hussien , 2019Description: 119 P. : charts , facsimiles ; 25cmOther title:
  • التعبير المناعى لإم جى إم تى فى سرطان القولون و المستقيم : دراسه مناعيه هستوكيميائيه وهستوباثولوجيه [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology Summary: Backgroud: Globally Colorectal carcinoma (CRC) is the third most common cancer in the world. There is an urgent need to identify predictive markers for CRC progression and treatment. Aim: This study aimed to assess immunohistochemical expression of MGMT in CRC and correlation of this expression with the clinico-pathological aspects of the tumor, carried on 70 colectomy using formalin fixed paraffin embedded tumor tissue. Results: MGMT expression status was significantly correlated with tumor stage and metastatic status (p-value 0.0146 and 0.0392 respectively), and showed a statistically nonsignificant direct linear correlation with primary tumor (T) invasiveness, while it was not correlated with age, sex, size, site, histologic grade , type , nodal status ,vascular or perineural invasion (p- value > 0.05). Conclusions: Our results are favoring that MGMT expression can be correlated with CRC progression and might be a valuable biomarker in selection of metastatic and recurrent cases to benefit from alkylating chemotherapeutics as ,Temozolomide
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.Ph.D.2019.Mo.E (Browse shelf(Opens below)) Not for loan 01010110080205000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.Ph.D.2019.Mo.E (Browse shelf(Opens below)) 80205.CD Not for loan 01020110080205000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology

Backgroud: Globally Colorectal carcinoma (CRC) is the third most common cancer in the world. There is an urgent need to identify predictive markers for CRC progression and treatment. Aim: This study aimed to assess immunohistochemical expression of MGMT in CRC and correlation of this expression with the clinico-pathological aspects of the tumor, carried on 70 colectomy using formalin fixed paraffin embedded tumor tissue. Results: MGMT expression status was significantly correlated with tumor stage and metastatic status (p-value 0.0146 and 0.0392 respectively), and showed a statistically nonsignificant direct linear correlation with primary tumor (T) invasiveness, while it was not correlated with age, sex, size, site, histologic grade , type , nodal status ,vascular or perineural invasion (p- value > 0.05). Conclusions: Our results are favoring that MGMT expression can be correlated with CRC progression and might be a valuable biomarker in selection of metastatic and recurrent cases to benefit from alkylating chemotherapeutics as ,Temozolomide

Issued also as CD

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