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Type I interferon signature in Egyptian patients with systemic lupus erythematosus / Mahmoud Mohamed Hussien Ghanema ; Supervised Manal Mohamed Abdelmoneim , Olfat Gamil Shaker , Ahmed Mohamed Ahmed Hussein Fayed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mahmoud Mohamed Hussien Ghanema , 2019Description: 134 P. : facsimiles ; 25cmOther title:
  • دور الإنترفيرون من النوع الأول فى تشخيص الذئبة الحمراء فى المرضى المصريين سواء بالتهاب فى الكلى او بدونه [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine Summary: Topic and aims: This study assesses Interferon-alpha in systemic lupus erythematosus, the use of interferon alpha as a biomarker in Egyptian lupus patients and investigates the relationship between interferon alpha and lupus activity. Methods: The present study was a cross-sectional descriptive study that carried at outpatient internal medicine clinic of Rheumatology and clinical immunology as well as inpatient internal medicine departments of Kasr Elaini hospital. The study includes 30 Egyptian patients with SLE disease without renal affection, 30 Egyptian patients with lupus nephritis, as well as 30 (age and sex matched) apparently healthy Egyptian volunteers. Serum was used for determination of interferon alpha using ELISA kit that was provided by bioassay technology laboratory, shanghai, China (Cat. No E0076Hu). Results: There is a statistically significant difference in type1 Interferon level between SLE patients without nephritis and control groups with p value< 0.001. There is a statistically significant difference in type1 Interferon level between lupus nephritis patients and control groups with p value< 0.001. There is a statistically significant correlation between type 1 interferon level and ANA titre with a statistical significance (p value = 0.003)
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.M.Sc.2019.Ma.T (Browse shelf(Opens below)) Not for loan 01010110080026000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.M.Sc.2019.Ma.T (Browse shelf(Opens below)) 80026.CD Not for loan 01020110080026000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

Topic and aims: This study assesses Interferon-alpha in systemic lupus erythematosus, the use of interferon alpha as a biomarker in Egyptian lupus patients and investigates the relationship between interferon alpha and lupus activity. Methods: The present study was a cross-sectional descriptive study that carried at outpatient internal medicine clinic of Rheumatology and clinical immunology as well as inpatient internal medicine departments of Kasr Elaini hospital. The study includes 30 Egyptian patients with SLE disease without renal affection, 30 Egyptian patients with lupus nephritis, as well as 30 (age and sex matched) apparently healthy Egyptian volunteers. Serum was used for determination of interferon alpha using ELISA kit that was provided by bioassay technology laboratory, shanghai, China (Cat. No E0076Hu). Results: There is a statistically significant difference in type1 Interferon level between SLE patients without nephritis and control groups with p value< 0.001. There is a statistically significant difference in type1 Interferon level between lupus nephritis patients and control groups with p value< 0.001. There is a statistically significant correlation between type 1 interferon level and ANA titre with a statistical significance (p value = 0.003)

Issued also as CD

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