Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Introduction: Pulmonary vascular disease is the end stage point of pulmonary arterial hypertension resulting from shunt lesions. Calculation of Rp/Rs using Fick{u2019}s principle is mandatory and gold standard for differentiation between reversible and irreversible pulmonary hypertension in the context of shunt lesions. RDW is an important RDW is one of the parameters in complete blood count (CBC) that measures variation in red blood cell size or vol»ume (anisocytosis). The most common cause of an elevated RDW is anemia. Higher erythropoesis due to hypoxia can also lead to increased RDW. The aim of this study is to examine the predictive value of RDW as well as right and left ventricular systo-diastolic functions in differentiating patients with reversible and irreversible pulmonary hypertension as diagnosed by invasive hemodynamics. Methods: 40 patients divided into two groups a group with irreversible PHTN (13) and a group with reversible PHTN (17) by cardiac catheterization had their RDW retrieved and were exposed to 3D speckle tracking echocardiography for measurement of LV GLS and RV GLS as well as RV E/E{u2019} and LV E/E{u2019} by conventional and tissue doppler imaging. Sensitivity and specificity for discrimination between the 2 groups have been calculated

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