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Evaluation of the potential role of bone marrow mesenchymal stem cells in reversing doxorubicin induced male infertility in rats / Mennatallah Hany Abdelaziz Abdelbaki ; Supervised Abdelrahman Tawfik , Eman Youssri Salah Eldin , Mai Helmy Abdelgwad

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mennatallah Hany Abdelaziz Abdelbaki , 2019Description: 135 P. : charts , facsimiles , photographs ; 25cmOther title:
  • تقييم الدور المحتمل للخلايا الجذعية الوسيطة لنخاع العظام فى معالجة عقم الذكور المستحث بواسطة عقار الدوكسوروبيسين فى الجرذان [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science, - Department of Zoology Summary: Background: Many therapies to treat cancer are gonadotoxic and can lead to infertility. New strategies to diminish the side effects and protective plans during and after chemotherapy are needed. Therefore, bone marrow mesenchymal stem cells (BM-MSCs) as a novel solution were investigated against doxorubicin (Dox)- induced toxicity in rat testes. Methods: Forty male albino prepubertal rats were divided into four groups, ten rats per each group. The first was injected intraperitoneally with saline as control. The second group was injected intravenously with a single dose of BM-MSCs (2{u00D7}10⁶ cells). The third was injected intraperitoneally with a single dose of Dox (5 mg /kg b.wt). The fourth was injected with both Dox and BM-MSCs as previously mentioned. Rats were cohabited each separately with an untreated adult female after 8 weeks of treatment to examine Dox effects on male's fertility. Results: BM-MSCs counteract the deleterious effects of Dox on body, testicular weight as well as sperm quality by increasing sperm concentration and reducing the rate of abnormal sperm. BM-MSCs reduced significantly the testicular oxidative stress by reducing the elevated level of MDA and increasing the antioxidant capacity. Histologically, the testicular atrophy, severe damage of spermatogenesis, and the significant reduction of the diameter and germinative cell layer thickness of the seminiferous tubules caused by Dox were significantly recovered after administration of the BM-MSCs
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2019.Me.E (Browse shelf(Opens below)) Not for loan 01010110080331000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2019.Me.E (Browse shelf(Opens below)) 80331.CD Not for loan 01020110080331000

Thesis (M.Sc.) - Cairo University - Faculty of Science, - Department of Zoology

Background: Many therapies to treat cancer are gonadotoxic and can lead to infertility. New strategies to diminish the side effects and protective plans during and after chemotherapy are needed. Therefore, bone marrow mesenchymal stem cells (BM-MSCs) as a novel solution were investigated against doxorubicin (Dox)- induced toxicity in rat testes. Methods: Forty male albino prepubertal rats were divided into four groups, ten rats per each group. The first was injected intraperitoneally with saline as control. The second group was injected intravenously with a single dose of BM-MSCs (2{u00D7}10⁶ cells). The third was injected intraperitoneally with a single dose of Dox (5 mg /kg b.wt). The fourth was injected with both Dox and BM-MSCs as previously mentioned. Rats were cohabited each separately with an untreated adult female after 8 weeks of treatment to examine Dox effects on male's fertility. Results: BM-MSCs counteract the deleterious effects of Dox on body, testicular weight as well as sperm quality by increasing sperm concentration and reducing the rate of abnormal sperm. BM-MSCs reduced significantly the testicular oxidative stress by reducing the elevated level of MDA and increasing the antioxidant capacity. Histologically, the testicular atrophy, severe damage of spermatogenesis, and the significant reduction of the diameter and germinative cell layer thickness of the seminiferous tubules caused by Dox were significantly recovered after administration of the BM-MSCs

Issued also as CD

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