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The possible prophylactic role of l-carnitine on induced renal ischemia-reperfusion injury in adult male albino rat : A histological, biochemical and immunohistochemical study / Muhammad Hani Muhammad ; Supervised Safwat Wadea Gerges , Ayman Aboelenein Rizk , Waleed Ahmed Badawy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Muhammad Hani Muhammad , 2019Description: 77 P. : charts , facimiles ; 25cmOther title:
  • الدور الوقائى المحتمل لعقار الإل- كارنيتين على الإصابة الناتجة عن قصور الإمداد الدموى المستحث وإعادة التروية فى كلية الجرذ الأبيض الذكر البالغ : دراسة هستولوجية و كيميائية حيوية وهستوكيميائية مناعية [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Anatomy Summary: Renal ischemia reperfusion injury can lead to organ dysfunction or failure and is a serious clinical problem during renal transplantation , shock or major surgery. Aim of the work: Was to investigate the possible protective role L-carnitine versus induced renal ischemia reperfusion injury in adult male albino rat using histological, biochemical and immunohistochemical methods. Material and methods: This study was conducted on 50 adult male albino rats were divided into 3 groups: control group, induced ischemia reperfusion group and L-carnitine pretreated groups (before induction of ischemia).All these groups underwent histological study using Hx.and E stain, PAS stain and caspase-3 stain.Biochemical study was done using blood samples to detect the serum urea and creatinine levels.Histochemical study was done todetect the levels of MDA ,SOD and GSH .Histomorphometric study was done to detect the mean optical density of PAS stain and the mean area percentage of caspase- 3immunoexpression.All these investigations underwent statistical analysis Results: the present study has found that the pretreatment with L-carnitine has improved the renal functions,decreased the MDA levels,increased SOD and GSH levels with restoring the normal renal arcitechture with reduced areas of apoptotic cells, blood extravasation,pyknotic nuclei and vacuolated cells
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.02.M.Sc.2019.Mu.P (Browse shelf(Opens below)) Not for loan 01010110080362000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.02.M.Sc.2019.Mu.P (Browse shelf(Opens below)) 80362.CD Not for loan 01020110080362000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Anatomy

Renal ischemia reperfusion injury can lead to organ dysfunction or failure and is a serious clinical problem during renal transplantation , shock or major surgery. Aim of the work: Was to investigate the possible protective role L-carnitine versus induced renal ischemia reperfusion injury in adult male albino rat using histological, biochemical and immunohistochemical methods. Material and methods: This study was conducted on 50 adult male albino rats were divided into 3 groups: control group, induced ischemia reperfusion group and L-carnitine pretreated groups (before induction of ischemia).All these groups underwent histological study using Hx.and E stain, PAS stain and caspase-3 stain.Biochemical study was done using blood samples to detect the serum urea and creatinine levels.Histochemical study was done todetect the levels of MDA ,SOD and GSH .Histomorphometric study was done to detect the mean optical density of PAS stain and the mean area percentage of caspase- 3immunoexpression.All these investigations underwent statistical analysis Results: the present study has found that the pretreatment with L-carnitine has improved the renal functions,decreased the MDA levels,increased SOD and GSH levels with restoring the normal renal arcitechture with reduced areas of apoptotic cells, blood extravasation,pyknotic nuclei and vacuolated cells

Issued also as CD

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