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Detection of KIT mutations in core binding factor acute myeloid leukemia / Passant Badr Mohammed Sayed ; Supervised Bahia Yehia Riyad , Nayera Hamdy Elshakankiry , Ghada Mohamed Elsayed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Passant Badr Mohammed Sayed , 2019Description: 100 P. : charts , facsimiles ; 25cmOther title:
  • الكشف عن الطفرة الجينيه كيت لعامل الربط الأساسى فى سرطان الدم الميلودى الحاد [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology Summary: Subsets of patients with core binding factor acute myeloid leukemia may relapse after the first complete remission. We have investigated the frequency and the effect of KIT mutations on the outcome of patients with CBF-AML. 69 patients (35 pediatrics and 34 adults) with CBF-AML were enrolled in the study. The frequency of KIT mutations was higher in adults compared to pediatrics (22.9% and 14.7%, p=0.38) respectively. Leukocytosis {u2265}20x109 /L was significantly associated with pediatrics compared to adults, (64.7%vs 40%, p=0.04) respectively. t(8;21)(q22;22) was significantly associated with thrombocytopenia {u2264} 20x109 /L compared to inv (16) in adults (50% vs 7.7%, p=0.01). We conclude that children CBF-AML presents with leukocytosis.Thrombocytopenia is an adverse prognostic factor in adults CBF-AML. t(8;21) is associated with thrombocytopenia in CBF- AML
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.25.M.Sc.2019.Pa.D (Browse shelf(Opens below)) Not for loan 01010110080401000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.25.M.Sc.2019.Pa.D (Browse shelf(Opens below)) 80401.CD Not for loan 01020110080401000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology

Subsets of patients with core binding factor acute myeloid leukemia may relapse after the first complete remission. We have investigated the frequency and the effect of KIT mutations on the outcome of patients with CBF-AML. 69 patients (35 pediatrics and 34 adults) with CBF-AML were enrolled in the study. The frequency of KIT mutations was higher in adults compared to pediatrics (22.9% and 14.7%, p=0.38) respectively. Leukocytosis {u2265}20x109 /L was significantly associated with pediatrics compared to adults, (64.7%vs 40%, p=0.04) respectively. t(8;21)(q22;22) was significantly associated with thrombocytopenia {u2264} 20x109 /L compared to inv (16) in adults (50% vs 7.7%, p=0.01). We conclude that children CBF-AML presents with leukocytosis.Thrombocytopenia is an adverse prognostic factor in adults CBF-AML. t(8;21) is associated with thrombocytopenia in CBF- AML

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