Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy

Aloe genus plants, distributed in old world, are widely known and have been used for centuries as topical and oral therapeutic agents due to their health, beauty, medicinal and skin care properties. Among the well-investigated Aloe species are A. arborescence, A. ferox and A. vera. Today, they account among the most economically important medicinal plants and are commonly used in health treatment where they play a vital role in the treatment of various types of diseases besides being rich source of valuable phytochemicals. This work includes phytochemical and biological investigations of Aloe thraskii Baker, which very few work was traced in the available literature, aiming to find other common Aloe species with medicinal value. The study includes the genetic profiling, phytochemical screening, proximate analysis, LC/MS profiling, isolation of its major constituents and biological study of the species under investigation. The leaves were subjected to biological and chemical studies. In this respect, the antioxidant, cytotoxic and anti-inflammatory potentials of the ethanolic (90%) extract of the tested sample were assessed in-vitro, Moreover for its in-vivo anti-inflammatory, anti-rheumatic and anti-oxidant activities. Meanwhile, the chemical composition of the leaves was examined through qualitative and quantitative analyses of the phenolic and flavonoid components

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