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Study of teratogenic effects after verapamil administration in pregnant albino rats / Nawal Ahmed Sayed Ibrahium Elabasawy ; Supervised Mohamed Ahmed Badwy , Abdelwahab Elghareeb , Heba Ali Abdelrahman

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Nawal Ahmed Sayed Ibrahium Elabasawy , 2019Description: 98 P. : charts , facsimiles ; 25cmOther title:
  • دراسة التأثيرات المشوهة بعد تناول عقار فيراباميل على الجزران البيضاء الحوامل [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology Summary: This study was conducted in an attempt to prove the teratogenic potential of Verapamil on pregnant rat's offspring. Female rats were administrated with Verapamil (0.1 mg/Kg) by gastric tube from 5th to 19th day of pregnancy. At 20th day the animals were sacrificed and dissected in order to remove the uterus then open it to get the fetuses and record the mortality rate, growth parameters, skeletal malformations, histological study of placenta, fetal liver, mother liver.The results could be summarized in the following points: The pregnant rats treated orally with therapeutically dose of Verapamil during gestation period (5th - 19 th) showed no external signs of toxicity (nasal or vaginal bleeding) and no mortality cases were recorded but there was a non-significant decrease in the mother weight gain of the treated group when compared with the control.There was a significant decrease in the placental weight throughout the treated group (0.395± 0.022a ) when compared with the control (0.515 ± 0.08).The treated pregnant rat's uterus showed asymmetrical distribution of fetuses in the two uteri horns and reduced number of fetuses, uterine horns showing clearly visible embryonic resorbed sites.The treated group showed a reduction in the pre-implantation loss index % and increased in the pre- and post-implantation loss index% There were a significant (P{u2264} 0.05) reduction in fetus weight (1.80 ± 1.48a ) of animals from treated group in comparison with the control one (2.900 ± 0.775)
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.25.M.Sc.2019.Na.S (Browse shelf(Opens below)) Not for loan 01010110080611000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.25.M.Sc.2019.Na.S (Browse shelf(Opens below)) 80611.CD Not for loan 01020110080611000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology

This study was conducted in an attempt to prove the teratogenic potential of Verapamil on pregnant rat's offspring. Female rats were administrated with Verapamil (0.1 mg/Kg) by gastric tube from 5th to 19th day of pregnancy. At 20th day the animals were sacrificed and dissected in order to remove the uterus then open it to get the fetuses and record the mortality rate, growth parameters, skeletal malformations, histological study of placenta, fetal liver, mother liver.The results could be summarized in the following points: The pregnant rats treated orally with therapeutically dose of Verapamil during gestation period (5th - 19 th) showed no external signs of toxicity (nasal or vaginal bleeding) and no mortality cases were recorded but there was a non-significant decrease in the mother weight gain of the treated group when compared with the control.There was a significant decrease in the placental weight throughout the treated group (0.395± 0.022a ) when compared with the control (0.515 ± 0.08).The treated pregnant rat's uterus showed asymmetrical distribution of fetuses in the two uteri horns and reduced number of fetuses, uterine horns showing clearly visible embryonic resorbed sites.The treated group showed a reduction in the pre-implantation loss index % and increased in the pre- and post-implantation loss index% There were a significant (P{u2264} 0.05) reduction in fetus weight (1.80 ± 1.48a ) of animals from treated group in comparison with the control one (2.900 ± 0.775)

Issued also as CD

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