Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Oncology (Surgical)

In the current study, we report our experience with borderline ovarian tumors, and include a summary of the current literature to provide a reference for the management of this disease. We collected and analyzed retrospective data on the pathology, management, disease free survival (DFS) of patients with BOTs who underwent surgical management at or were referred to department of surgical oncology, National Cancer Institute, Cairo University (NCI) from January 2013 to December 2017. This retrospective cohort study included 69 cases.The mean age of our patients at the time of surgery is 41.3 years with 52.17 % of them below the age of 40. The most common stage of the disease was stage IA and only two cases developed metastasis. Serous BOT was the most common pathology followed by mucinous BOT. The most common surgical complication was ureteric injury. Bilateral tumors were found in 27.5 % of cases. 4 patients underwent fertility sparing surgery via laparoscopy. 10.1 % of cases received adjuvant chemotherapy. 50.7 % of cases underwent fertility sparing surgery, while radical surgery was performed for 49.3 %. Higher recurrence rate was found in the fertility sparing group. All patients who underwent fertility sparing surgery had normal menstrual cycle. Successful pregnancy occurred in 41.1 % of patients who desired fertility after surgery. Overall disease-free survival (DFS) was 90.164 months. The most important prognostic factors were disease stage, presence of peritoneal implants and surgical approach

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