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Hotair (homeobox antisense intergenic rna) and gas-5 (growth arrest{u2013}specific 5) expressions as biomarkers for early diagnosis of multiple sclerosis (MS) / Marwa Kamel Mohamed Fahmy Kamel ; Supervised Olfat Gamil Shaker , Amr Hassan , Nermien Esmat Waly

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Marwa Kamel Mohamed Fahmy Kamel , 2020Description: 115 P. : charts , facsimiles ; 25cmOther title:
  • تمثيل الجينات كعلامات حيويه للتشخيص المبكر لمرض التصلب المتعدد GAS5 & HOTAIR [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry Summary: Aims: Long non-coding RNAs (lncRNAs) were believed to play a role in the pathogenesis of many neurological disorders. We investigated the expression of two lncRNAs; HOTAIR and GAS-5 in patients with multiple sclerosis (MS) to clarify their role in MS pathogenesis and their impact on clinical course of the disease. Methods: This case-control study was conducted on 134 subjects; 74 patients with MS fulfilling the revised McDonald criteria and 60 healthy age- and sex- matched control. The clinical disability was evaluated using the expanded disability status scale (EDSS). lncRNAs expression was performed using Quantitative RT-PCR for the two lncRNAs; HOTAIR and GAS-5. Results: HOTAIR was found to be significantly down-regulated in MS patients (p< 0.001). GAS-5 was found to be significantly up-regulated in MS patients (p=0.002). GAS-5 expression was significantly higher in male patients than female patients (p=0.049), patients who initially represented with weakness had significantly higher expression levels of GAS-5 as compared to patients with ataxia (p=0.008)
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.03.Ph.D.2020.Ma.H (Browse shelf(Opens below)) Not for loan 01010110080808000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.03.Ph.D.2020.Ma.H (Browse shelf(Opens below)) 80808.CD Not for loan 01020110080808000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry

Aims: Long non-coding RNAs (lncRNAs) were believed to play a role in the pathogenesis of many neurological disorders. We investigated the expression of two lncRNAs; HOTAIR and GAS-5 in patients with multiple sclerosis (MS) to clarify their role in MS pathogenesis and their impact on clinical course of the disease. Methods: This case-control study was conducted on 134 subjects; 74 patients with MS fulfilling the revised McDonald criteria and 60 healthy age- and sex- matched control. The clinical disability was evaluated using the expanded disability status scale (EDSS). lncRNAs expression was performed using Quantitative RT-PCR for the two lncRNAs; HOTAIR and GAS-5. Results: HOTAIR was found to be significantly down-regulated in MS patients (p< 0.001). GAS-5 was found to be significantly up-regulated in MS patients (p=0.002). GAS-5 expression was significantly higher in male patients than female patients (p=0.049), patients who initially represented with weakness had significantly higher expression levels of GAS-5 as compared to patients with ataxia (p=0.008)

Issued also as CD

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