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Immunohistochemical expression of stem cell markers aldh1, cd44 in urothelial carcinoma of the urinary bladder / Sabrine Ali Ahmad Ali ; Supervised Nour Elhoda Ismael , Lubna Omar Elfarouk Abdelsalam , Suzan Mohamad Talaat Mohamad

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Sabrine Ali Ahmad Ali , 2019Description: 166 P. : charts , facsimiles ; 25cmOther title:
  • التعبير المناعى الهستوكيميائى لدلالات الخلايا الجذعية ايه ال دى اتش1 و سى دى 44 فى أورام الظهارة البولية للمثانة البولية [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology Summary: Bladder cancer, is the sixth most prevalent cancer in men worldwide. In Egypt, it is the second most common malignancy among Egyptian males. Urothelial carcinoma represents about 90% of all primary tumors of the urinary bladder. Aim of the work: Is to study the expression of stem cell markers ALDH1 and CD44 and their relation to different clinicopathological parameters in urinary bladder urothelial carcinoma cases. Material and methods: This study included 60 urothelial bladder carcinoma specimens obtained by radical cystectomy and trans-urethral resection of tumors. Results: There was no statistically significant relationship between ALDH1 expression and most of the different clinicopathological parameters while there was statistically significant relationship between ALDH1 expression and the presence of bilharziasis.There was no statistically significant relationship between CD44 expression and all clinic pathological parameters. Conclusion: There was statistically significant relationship between ALDH1 expression and the presence of bilharziasis. Further studies were needed to determine the possibility of considering ALDH1 expression in the urothelial carcinoma a prognostic factor
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.Ph.D.2019.Sa.I (Browse shelf(Opens below)) Not for loan 01010110080891000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.Ph.D.2019.Sa.I (Browse shelf(Opens below)) 80891.CD Not for loan 01020110080891000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology

Bladder cancer, is the sixth most prevalent cancer in men worldwide. In Egypt, it is the second most common malignancy among Egyptian males. Urothelial carcinoma represents about 90% of all primary tumors of the urinary bladder. Aim of the work: Is to study the expression of stem cell markers ALDH1 and CD44 and their relation to different clinicopathological parameters in urinary bladder urothelial carcinoma cases. Material and methods: This study included 60 urothelial bladder carcinoma specimens obtained by radical cystectomy and trans-urethral resection of tumors. Results: There was no statistically significant relationship between ALDH1 expression and most of the different clinicopathological parameters while there was statistically significant relationship between ALDH1 expression and the presence of bilharziasis.There was no statistically significant relationship between CD44 expression and all clinic pathological parameters. Conclusion: There was statistically significant relationship between ALDH1 expression and the presence of bilharziasis. Further studies were needed to determine the possibility of considering ALDH1 expression in the urothelial carcinoma a prognostic factor

Issued also as CD

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