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In vitro studies of anticancer loaded-polymeric nanocapsules / Omnia Maher Mahmoud Elsayed ; Supervised Abdelgawad Ali Fahmi , Mohamed Abbas Shemis , Mariam Abdur-Rahman Hassan Mahmoud

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Omnia Maher Mahmoud Elsayed , 2019Description: 133 P. : charts , photographs ; 25cmOther title:
  • دراسات مختبرية للكابسولات النانونية البوليميرية المحملة بمضادات السرطان [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology Summary: Nanocapsules based drug delivery system has provided an efficient tools in cancer treatment in recent times. The toxicity of anticancer drugs can be decreased through nano-encapsulation using polymeric nanocapsules. This study aimed to synthesis, optimization and characterization of doxorubicin (Dox) loaded biodegradable polycaprolactone (PCL) nanocapsules. Dox loaded PCL nanocapsules were prepared by double emulsion method using dichloromethane as the organic solvent, and polyvinyl alcohol as the external aqueous phase. Formulation parameter such as the effect of weight ratio of drug to polymer was optimized for the synthesis of Dox-PCL nanocapsules. Different weight ratio of Dox loaded PCL nanocapsules (1:20), (1:50) and (3:10) were prepared. Dox-PCL nanocapsules of weight ratio of 3:10 mg had higher DL of 16.88 % than other cases and its average size determined by dynamic light scattering (DLS) was 212 nm. The TEM image revealed that the prepared nanocapsules were spherical in shape in all cases. Also, ZPs were greater in case of Dox-PCL with ratio of 3:10 mg than other cases, which suggests good stability these synthesized nanocapsules. Finally, these results indicate that the properties such as DL %, morphology, size and surface charge of the nanocapsules colloidal suspension were better with decreasing the amount of PCL and increasing the amount of Dox
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.25.M.Sc.2019.Om.I (Browse shelf(Opens below)) Not for loan 01010110080918000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.25.M.Sc.2019.Om.I (Browse shelf(Opens below)) 80918.CD Not for loan 01020110080918000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology

Nanocapsules based drug delivery system has provided an efficient tools in cancer treatment in recent times. The toxicity of anticancer drugs can be decreased through nano-encapsulation using polymeric nanocapsules. This study aimed to synthesis, optimization and characterization of doxorubicin (Dox) loaded biodegradable polycaprolactone (PCL) nanocapsules. Dox loaded PCL nanocapsules were prepared by double emulsion method using dichloromethane as the organic solvent, and polyvinyl alcohol as the external aqueous phase. Formulation parameter such as the effect of weight ratio of drug to polymer was optimized for the synthesis of Dox-PCL nanocapsules. Different weight ratio of Dox loaded PCL nanocapsules (1:20), (1:50) and (3:10) were prepared. Dox-PCL nanocapsules of weight ratio of 3:10 mg had higher DL of 16.88 % than other cases and its average size determined by dynamic light scattering (DLS) was 212 nm. The TEM image revealed that the prepared nanocapsules were spherical in shape in all cases. Also, ZPs were greater in case of Dox-PCL with ratio of 3:10 mg than other cases, which suggests good stability these synthesized nanocapsules. Finally, these results indicate that the properties such as DL %, morphology, size and surface charge of the nanocapsules colloidal suspension were better with decreasing the amount of PCL and increasing the amount of Dox

Issued also as CD

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