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Study of miR-146a and miR-196a polymorphisms in patients with non-hodgkin lymphoma / Doaa Salah Mahmoud ; Supervised Hala Shiba , Sahar Kamal Eldin , Somaia Abdelrahman Mousa

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Doaa Salah Mahmoud , 2019Description: 140 P. ; 25cmOther title:
  • دراسة التعدد الجينى لميكرو آر إن إيه ١٤٦أ و ميكرو آر إن إيه ١٩٦أ٢ فى مرضى سرطان الغدد الليمفاويه الغير هودجكين [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Background:Non-hodgkin lymphoma (NHL) encompass a heterogeneous group of cancers with a wide range of histological appearances and clinical features at presentation. Several single nucleotide polymorphisms (SNPs) are considered to have significant impacts on susceptibility to the development of cancer.The miR-146a & miR-196a2 polymorphisms have been reported to be associated with the risk of cancer diseases. Objective: to investigate the relation between miR-146a and miR-196a2 polymorphisms and risk as well as prognosis of B -cell NHL. Methods:The genotyping of miR-146a (rs2910164) and miR-196a2 (rs11614913) polymorphisms were detected by polymerase chain reaction{u2013}restriction fragment length polymorphism (PCR{u2013}RFLP) for 75 B-NHL patients and 100 healthy control. Results: The study revealed that there was no significant association between miR-146a and miR-196a2 polymorphisms and risk of B-NHL. Analysis of the association between this polymorphism and the survival of B-NHL patients showed that miR-146a (GC and CC) genotypes have longer Disease Free Survival (DFS) compared with GG genotype (p=0.044).Regarding miR-196a2 polymorphism, patients having (CT and TT) genotypes have longer DFS compared with those having CC genotype (p=0.009). Conclusion:miR-146a and miR-196a2 genetic polymorphisms might be considered as a prognostic marker in B-NHL in Egyptians
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2019.Do.S (Browse shelf(Opens below)) Not for loan 01010110080919000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2019.Do.S (Browse shelf(Opens below)) 80919.CD Not for loan 01020110080919000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Background:Non-hodgkin lymphoma (NHL) encompass a heterogeneous group of cancers with a wide range of histological appearances and clinical features at presentation. Several single nucleotide polymorphisms (SNPs) are considered to have significant impacts on susceptibility to the development of cancer.The miR-146a & miR-196a2 polymorphisms have been reported to be associated with the risk of cancer diseases. Objective: to investigate the relation between miR-146a and miR-196a2 polymorphisms and risk as well as prognosis of B -cell NHL. Methods:The genotyping of miR-146a (rs2910164) and miR-196a2 (rs11614913) polymorphisms were detected by polymerase chain reaction{u2013}restriction fragment length polymorphism (PCR{u2013}RFLP) for 75 B-NHL patients and 100 healthy control. Results: The study revealed that there was no significant association between miR-146a and miR-196a2 polymorphisms and risk of B-NHL. Analysis of the association between this polymorphism and the survival of B-NHL patients showed that miR-146a (GC and CC) genotypes have longer Disease Free Survival (DFS) compared with GG genotype (p=0.044).Regarding miR-196a2 polymorphism, patients having (CT and TT) genotypes have longer DFS compared with those having CC genotype (p=0.009). Conclusion:miR-146a and miR-196a2 genetic polymorphisms might be considered as a prognostic marker in B-NHL in Egyptians

Issued also as CD

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