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Uses of Ý-diketone and active methylene compounds for the synthesis of heterocyclic derivatives with expected anti-tumor activities / Bishoy Anis Amin Ibrahim ; Supervised Rafat Milad Mohareb , Naglaa Yehia Samy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Bishoy Anis Amin Ibrahim , 2019Description: 124 P. : charts ; 25cmOther title:
  • استخدامات مركبات البيتا ثنائى الكيتون والمثلين النشطة لتحضير مشتقات غير متجانسة الحلقة ذات انشطة متوقعة مضادة للأورام [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry Summary: The N-(p-substituted)propnamide derivatives 3a,b were obtained through the reaction of ethyl benzoyl acetate with either of aniline of 4-chloroaniline according the reported literature. The latter compound underwent a series of heterocyclization reactions to give thiophene, pyran and pyridine derivatives. The antitumor of the synthesized compounds against A549 (non-small cell lung cancer), H460 (human lung cancer), HT-29 (human colon cancer) and MKN-45 (human gastric cancer) cancer cell lines together with foretinib as the positive control by a MTT assay. Were measured. The results showed that some compounds were of high inhibitions
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.10.M.Sc.2019.Bi.U (Browse shelf(Opens below)) Not for loan 01010110080873000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.10.M.Sc.2019.Bi.U (Browse shelf(Opens below)) 80873.CD Not for loan 01020110080873000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry

The N-(p-substituted)propnamide derivatives 3a,b were obtained through the reaction of ethyl benzoyl acetate with either of aniline of 4-chloroaniline according the reported literature. The latter compound underwent a series of heterocyclization reactions to give thiophene, pyran and pyridine derivatives. The antitumor of the synthesized compounds against A549 (non-small cell lung cancer), H460 (human lung cancer), HT-29 (human colon cancer) and MKN-45 (human gastric cancer) cancer cell lines together with foretinib as the positive control by a MTT assay. Were measured. The results showed that some compounds were of high inhibitions

Issued also as CD

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