Evaluation of selected antioxidants as a complementary therapy for the commonly encountered skin diseases of dogs / Marwa Rabah Yousif Amer ; Supervised Adel Abdelbaset Mohamed Kubesy , Shaymaa Ismaiel Salem , Shimaa Ghanem Yehia Aref

Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Internal Medicine and Infectious Disease

Dermatological problems are one of the most commonly reported disorders encountered in small animal medicine. This current investigation was carried out on 60 selected dogs divided into five groups; apparently healthy group (11 dogs), pyoderma diseased group (10 dogs), dermatophytosis affected group (13 dogs), mange diseased group (8 dogs ) and tick and flea allergic dermatitis diseased group (18 dogs) to evaluate hematobiochemical parameters and oxidative stress biomarkers in diseased dogs when compared with apparently healthy dogs and to investigate the therapeutic effect of antioxidants supplements (vitamin A and vitamin C for dermatophytosis, zinc for pyoderma vitamin E and selenium for mange and allergic dermatitis) as complementary to the standard therapy. Blood, stool and skin samples were collected from all dogs and were analyzed before and after treatment for fungal investigation of hair shaft and skin, hematological examinations, oxidative stress biomarkers investigations (superoxide dismutase 2SOD3,Glutathione peroxidase 2GPX3, catalase enzyme 2CAT3 malondialdehyde 2MDA3), complete blood picture ,liver and kidney functions tests (ALT, AST, urea and creatinine).In mange group, there was leukocytosis, neutrophilia, significant increase in SOD and MDA and significant decrease in catalase and GPX while after treatment SOD was significantly decreased in antioxidant supplemented therapy, MDA was significantly decreased after classic and antioxidant supplemented treatment and catalase was significantly increased after classic and antioxidant supplemented therapy. In allergic dermatitis, there was thrombocytopenia, leukocytosis, high ALT and AST, low GPX and high MDA while after treatment GPX and catalase were significantly increased in antioxidant supplemented treatment. In pyoderma there was thrombocytopenia, neutrophilia, high ALT, AST, BUN, low GPX and catalase and high MDA but after treatment catalase was significantly raised

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