header
Image from OpenLibrary

The hepatoprotective effect of casein glycomacropeptide as compared to pterostilbene and curcumi / Mostafa Ahmed Mohamed Ameen Lotfy ; Supervised Mohamed Mohamed Elsayed Metwally , Alaa Mohamed Abdelfattah Ibrahim

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mostafa Ahmed Mohamed Ameen Lotfy , 2020Description: 100 P. : charts , photographs ; 25cmOther title:
  • تأثير الكازين جليكوماكروببتيد الواقى للكبد مقارنة بمادتى البتيروستيلبين و الكركمين [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Agriculture - Department of Dairy Summary: This study was conducted to study the effect of feeding of casein glycomacropeptide (CGMP) on alleviating different stages of liver fibrosis developed in male adult Wistar albino rats by their injection with CCl4. Moreover, it was to compare the improvement effect of CGMP with the effect of pterostilbene and curcumin as a proposed effective polyphenols for treating liver fibrosis. Liver functions, liver histopathology and fibrotic parameters were examined. Also, the effect on kidney functions and histology were determined. Two experiments were carried out to study the following: The comparison between the beneficial effect of feeding CGMP (50 and 100 mg/kg), curcumin (100 mg/kg) and pterostilbene (15 and 40 mg/kg) on liver of rats injected with CCl4 for 5 weeks. Determination of the beneficial effect of feeding CGMP (150 mg/kg) on rats already developed liver fibrosis by their injection with CCl4 for 5 weeks before starting feeding. This was also compared with feeding rats with CGMP (150 mg/kg) coincided with CCl4 injection. CGMP (100 mg) and pterostilbene (40 mg) significantly improved liver functions with no significant differences between both items. Both significantly reduced liver enzymes ALT, AST and ALP, reduced MDA, LDH and bilirubin and increased the antioxidants CAT, SOD and GPx. Lower concentrations of both additives showed less improvement. Curcumin improved the above functions but with a lower percentage than pterostilbene (40 mg) and CGMP (100 mg). CGMP (150 mg/kg) significantly improved the functions of fibrotic liver and in particular ALT and greatly increased the antioxidants CAT, SOD and GPx than all other ingredients. This means a good reduction of oxidative stress in liver and might be proof that the effect of CGMP would last longer than the polyphenols
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.07.07.M.Sc.2020.Mo.H (Browse shelf(Opens below)) Not for loan 01010110080945000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.07.07.M.Sc.2020.Mo.H (Browse shelf(Opens below)) 80945.CD Not for loan 01020110080945000

Thesis (M.Sc.) - Cairo University - Faculty of Agriculture - Department of Dairy

This study was conducted to study the effect of feeding of casein glycomacropeptide (CGMP) on alleviating different stages of liver fibrosis developed in male adult Wistar albino rats by their injection with CCl4. Moreover, it was to compare the improvement effect of CGMP with the effect of pterostilbene and curcumin as a proposed effective polyphenols for treating liver fibrosis. Liver functions, liver histopathology and fibrotic parameters were examined. Also, the effect on kidney functions and histology were determined. Two experiments were carried out to study the following: The comparison between the beneficial effect of feeding CGMP (50 and 100 mg/kg), curcumin (100 mg/kg) and pterostilbene (15 and 40 mg/kg) on liver of rats injected with CCl4 for 5 weeks. Determination of the beneficial effect of feeding CGMP (150 mg/kg) on rats already developed liver fibrosis by their injection with CCl4 for 5 weeks before starting feeding. This was also compared with feeding rats with CGMP (150 mg/kg) coincided with CCl4 injection. CGMP (100 mg) and pterostilbene (40 mg) significantly improved liver functions with no significant differences between both items. Both significantly reduced liver enzymes ALT, AST and ALP, reduced MDA, LDH and bilirubin and increased the antioxidants CAT, SOD and GPx. Lower concentrations of both additives showed less improvement. Curcumin improved the above functions but with a lower percentage than pterostilbene (40 mg) and CGMP (100 mg). CGMP (150 mg/kg) significantly improved the functions of fibrotic liver and in particular ALT and greatly increased the antioxidants CAT, SOD and GPx than all other ingredients. This means a good reduction of oxidative stress in liver and might be proof that the effect of CGMP would last longer than the polyphenols

Issued also as CD

There are no comments on this title.

to post a comment.