Vitamin D status in recently diagnosed epileptic children / Sarah Khalil Gamal Khalil Mohamed ; Supervised Hanan Abdallah Amer , Alaa Nabil Elmazny , Laila Ahmed Rashed

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry

Background: Several neurological disorders have been linked with vitamin D deficiency. Vitamin D deficiency in children with epilepsy is becoming an increasingly recognized health care concern. Most studies focused on effect of AEDs on vitamin D status but fewer studies focused on its status in recently diagnosed, treatment naïve patients. objectives: This study aimed to explore vitamin D status among recently diagnosed children with generalized idiopathic epilepsy and comparing it with healthy control. subjects and methods: The study was carried on forty-two recently diagnosed epileptic children (8-18 years old) and forty age and sex matched healthy control subjects. Serum vitamin D level as well as parathormone level was performed for all patients and control subjects. results: There was a statistically significant difference between patients and control (p value <0.001).There was also a statistically significant difference regarding serum vitamin D level between patients with higher seizure frequencyand patients with lower seizure frequency (p value =0.004).Patients with insufficient serum vitamin D levels had a significant lower age at onset of epilepsythan patients with deficientor normal levels (p value=0.046).There was a statistically significant negative correlation between duration of epilepsy in years and serum vitamin D level. Both vitamin D level and family history were found to be a significant predictor for developing IGEs in children(P value <0.001) for both.Serum vitamin D level distinguished patients with lower seizure frequency from patients with higher seizure frequency by ROC curve analysis

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