Sleep instability and disorders in temporal lobe epilepsy / Hend Ismail Ahmed Mogahed ; Supervised Amany Mahmoud Abdelhamed Rabah , Hala Rashad Elhabashy , Dalia Mohammed Labib

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry

Background:Sleep fragmentation and deprivationfacilitate the occurrence of epileptic seizures, also epileptiform activity and antiepileptic drugs(AEDs)affect normal sleep architecture objective:analysisof sleep disorders inTLE patients and effect of temporal lobe epilepsy and AEDs on sleep architecture. subjects and methods: The study was carried on 25 TLE patients and 20 healthy volunteers all participants completed questionnaires to evaluate their sleep (Epworth Sleepiness Scale [ESS]) and Hamilton Depression Questionnaire (HDS) and underwent, electroencephalogram(EEG) and overnightpolysomnography( PSG). results: TLE patients had a fragmented sleep with an increased number of night waking and time awake after sleep onset. Sleep onset latency and REM latency were prolonged with reduced REM% sleep, increased sleep stages (N1 and N2) and slow wave sleep reduction (N 3 andN 4) with increased arousal number and indices.A higher number of snores ,Apnea /Hypopnea index(AHI) andParoxysmal limb movement (PLM) was frequently observed in TLEpatientsand a significant +ve correlation between number of AEDs and arousal number and indices was observed. conclusion: Sleep disorders and fragmentation are more encountered in TLE epileptic patients compared to normal subjects. Also some AEDs affect sleep architecture and worsen sleep disorders which may affect seizures control

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