Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Industrial Pharmacy

Bone fractures is a worldwide public health issue and generated a significant socioeconomic impact characterized by a loss of bone mass and microarchitecture and accompanied with high rate of mortality and disability.Simvastatin (SIM) is a highly lipophilic anionic drug widely used as a lipid lowering agent.Other than hyperlipidemia, simvastatin has the ability to enhance bone formation when reached the bone in a specific doses with slow and sustained release pattern. Nanotechnology-based delivery systems has been successfully implemented in the development of controlleddrug delivery andspatial localization of the drug.This can be accomplished by using various types of polymers, especially biodegradable polymers.The work in this thesis was divided into three chapters: Chapter I: Formulation and characterization of simvastatin chitosan {u2013}tripolyphosphate nanoparticles.This chapter aims to formulate and optimize simvastatin loaded chitosan-tripolyphosphate nanoparticle (SIM CS-TPP NPs) using ionic gelation method to provide a local delivery system that control and sustain the release of simvastatin in the desired dose to promote bone regeneration. Box-Behnken design, a statistical experimental design, was adopted for optimization of the formulation variables of the prepared nanoparticles namely, CS percentage,TPP percentage and homogenization time. The optimized formula was selected and characterized by transmission electronic microscopy, in-vitro release, swelling index and storage stability

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