Biodegradable in-situ forming implant loaded with certain drug for improving bone healing / Fatma Samir Abdelsalam Elsebaei ; Supervised Seham A. Elkheshen , Emad B. Basalious , Azza A. Mahmoud

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Bone repair of large bone defects due to severe trauma, resection of bone tumours, reduced normal bone regeneration in cancer, vascular necrosis, and osteoporosis remains a great challenge in the field of orthopaedic surgery. Surgical treatment is the first line of treatment for bone injuries; however, the post-surgical healing process can be delayed due to other health issues or age. Therefore, a great attention has been given to the development of non-surgical injectable drug delivery systems, which have a simple application, local drug delivery for a site-specific action, sustained delivery periods, and enhanced patient compliance. Therefore, there is an increasing attention for the development of injectable in-situ forming implants (IFIs) for repairing serious bone injuries which need prolonged treatment period. IFIs can be injected using syringe into the body, and once injected they solidify to form a solid or semisolid depot. A variety of naturally and synthetically derived biodegradable materials have been utilized to form injectable in-situ forming systems. Biodegradable materials are natural or synthetic in origin and are degraded in-vivo, either enzymatically or non-enzymatically or both, to produce biocompatible, non-toxic by-products which are further eliminated by the normal metabolic pathways. The basic category of biomaterials used in drug delivery can be broadly classified as (1) synthetic biodegradable polymers, which includes relatively hydrophobic materials such as the Ü-hydroxy acids (a family that includes poly lactic-co-glycolic acid, PLGA), polyanhydrides, and others, and (2) naturally occurring polymers, such as complex sugars (hyaluronan and chitosan) and inorganic materials (hydroxyapatite)

Issued also as CD