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Therapeutic efficacy of osthole on dinitrobenze sulphonic acid induced-colitis in rats / Hanan Khairy Abouarab ; Supervised Mohamed Asem Said Marie , Abeer Mahamoud Badr , Hanan Mohamed Ebead Saleh

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Hanan Khairy Abouarab , 2019Description: 110 P. : charts , facsmailies; 25cmOther title:
  • الكفاءه العلاجيه للاوزول على التهاب القولون المستحث بدينيتروبنزين حمض السلفونيك فى الجرذان [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology Summary: Several mediators were associated with the pathogenesis of inflammatory bowel disease such as oxidative stress through the production of reactive oxygen metabolites, neutrophils infiltration and release of pro-inflammatory cytokines. This study was designed to investigate the therapeutic efficacy of osthole against dinitrobenzene sulfonic acid (DNBS) induced-colitis in rats through its anti- oxidant and anti-inflammatory properties. Colitis was induced in rats by single intracolonic instillation of (250 ol DNBS-25 mg/rat). Then 4 days later, rats were received oral administration of either (osthole 50 mg/kg), (sulfasalazine 500 mg/kg) or both in combination for 7 consecutive days. Body weight, some hematological parameters, colonic malondialdehyde (MDA) and myeloperoxidase activity (MPO), antioxidant parameters, colon injury and mucosa architectures were assessed. T helper (Th1)-related cytokines [Tumor necrosis factor alpha (TNF-Ü) and interferon-gamma (INF-Þ)], Th2-relarted cytokines (interleukin-4 [IL- 4 and IL-10], and Th-17 related cytokines [IL-17] were determined by ELISA. Osthole significantly improved the loss in body weight. That was accompanied with a remarkable amelioration of the disruption of the colonic architecture as well as a significant improvement in the antioxidant defense system. A reduction in MPO and MDA was observed in flamed colon
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2019.Ha.T (Browse shelf(Opens below)) Not for loan 01010110081246000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2019.Ha.T (Browse shelf(Opens below)) 81246.CD Not for loan 01020110081246000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology

Several mediators were associated with the pathogenesis of inflammatory bowel disease such as oxidative stress through the production of reactive oxygen metabolites, neutrophils infiltration and release of pro-inflammatory cytokines. This study was designed to investigate the therapeutic efficacy of osthole against dinitrobenzene sulfonic acid (DNBS) induced-colitis in rats through its anti- oxidant and anti-inflammatory properties. Colitis was induced in rats by single intracolonic instillation of (250 ol DNBS-25 mg/rat). Then 4 days later, rats were received oral administration of either (osthole 50 mg/kg), (sulfasalazine 500 mg/kg) or both in combination for 7 consecutive days. Body weight, some hematological parameters, colonic malondialdehyde (MDA) and myeloperoxidase activity (MPO), antioxidant parameters, colon injury and mucosa architectures were assessed. T helper (Th1)-related cytokines [Tumor necrosis factor alpha (TNF-Ü) and interferon-gamma (INF-Þ)], Th2-relarted cytokines (interleukin-4 [IL- 4 and IL-10], and Th-17 related cytokines [IL-17] were determined by ELISA. Osthole significantly improved the loss in body weight. That was accompanied with a remarkable amelioration of the disruption of the colonic architecture as well as a significant improvement in the antioxidant defense system. A reduction in MPO and MDA was observed in flamed colon

Issued also as CD

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