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Immunomodulatory eficacy of curcumin on streptozotocin - induced diabetic mice / Howida Sharkawy Abdalzaher Hassan ; Supervised Somaya Osman Eldeeb , Abeer Mahmoud Badr , Alyaa Ahmed Farid

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Howida Sharkawy Abdalzaher Hassan , 2019Description: 176 P. : charts , facsmailies ; 25cmOther title:
  • كفاءة التنظيم المناعى للكركومين على السكرى المستحث بالستربتوزوتوسين فى الفئران [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology Summary: Objective: This study aimed to assess the immunomodulatory effect of curcumin on innate and adaptive immune responses as well as its inhibitory power on hyperglycemia in streptozotocin (STZ)-induced diabetic CD1 mice. Materials & methods: The anti-diabetic effect was assessed by the estimation of glucose concentration after induction and during all investigated time points. Differential white blood cells analysis as well as levels of cytokines were measured in peripheral blood. In addition, histological evaluation and immunohistochemistry were applied at end of the study. Results: Hyperglycemia was markedly reduced after curcumin administration. Curcumin implied selective elevation in the count of lymphocytes and monocytes, and suppression of granulocytes count. Diabetic mice treated with curcumin showed lower levels of interferon (IFN)-Þ, interleukin (IL)-6, and IL-1Ý and higher levels of IL-2 than in diabetic mice. Histological alterations accompanied STZ-diabetes were ameliorated by curcumin administration. The pancreatic islet of treated diabetic mice displayed a decline in the immunostaining intensity of phosphorylated-nuclear factor-kB compared to diabetic mice. Conclusion: Thereby, these results suggest that curcumin has antidiabetic efficacy as it can regulate blood glucose levels, recover the damage caused to pancreatic Ý-cells and by its preferential immunomodulatory action on T helper1-related cytokines and immunosuppressive activity on proinflammatory cytokines
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2019.Ho.I (Browse shelf(Opens below)) Not for loan 01010110081252000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2019.Ho.I (Browse shelf(Opens below)) 81252 .CD Not for loan 01020110081252000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology

Objective: This study aimed to assess the immunomodulatory effect of curcumin on innate and adaptive immune responses as well as its inhibitory power on hyperglycemia in streptozotocin (STZ)-induced diabetic CD1 mice. Materials & methods: The anti-diabetic effect was assessed by the estimation of glucose concentration after induction and during all investigated time points. Differential white blood cells analysis as well as levels of cytokines were measured in peripheral blood. In addition, histological evaluation and immunohistochemistry were applied at end of the study. Results: Hyperglycemia was markedly reduced after curcumin administration. Curcumin implied selective elevation in the count of lymphocytes and monocytes, and suppression of granulocytes count. Diabetic mice treated with curcumin showed lower levels of interferon (IFN)-Þ, interleukin (IL)-6, and IL-1Ý and higher levels of IL-2 than in diabetic mice. Histological alterations accompanied STZ-diabetes were ameliorated by curcumin administration. The pancreatic islet of treated diabetic mice displayed a decline in the immunostaining intensity of phosphorylated-nuclear factor-kB compared to diabetic mice. Conclusion: Thereby, these results suggest that curcumin has antidiabetic efficacy as it can regulate blood glucose levels, recover the damage caused to pancreatic Ý-cells and by its preferential immunomodulatory action on T helper1-related cytokines and immunosuppressive activity on proinflammatory cytokines

Issued also as CD

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