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Hematological and renal phenotypes in pediatrics primary thrombotic microangiopathy / Mai Mohammed Emam ; Supervised Neveen Abdelmonem Soliman , Amina Abdelsalam Mahmoud Ali , Shereen Mahmoud Shawky

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mai Mohammed Emam , 2020Description: 99 P. : charts , facaimiles ; 25cmOther title:
  • التأثر الظاهرى فى الكلى والدم ى مرضى التهاب الاوعية الدموية التجلطيه الاولى فى الاطفال [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics Summary: Background:There has been a dramatic acceleration in the understanding of the pathogenesis of primary thrombotic microangiopathy (TMA) syndromes. This will create opportunities for specific treatments and the availability of specific treatments has created the need for rapid and specific diagnoses. Objective:was to provide a clinical description of primary thrombotic microangiopathy syndromes in the pediatric age group, and to identify the underlying immunological disturbances in such group of diseases. Methods: This cross sectional analytical study was conducted on 30 children with clinical and laboratory features suggestive of TMA at Cairo University Children Hospital at the period from August 2019 to February 2020. Shiga toxin screening (STEC),complement assay, ADAMT13 antigen concentration, homocysteine, CBC, urea&creatinine, coagulation profile and total& direct bilirubin were conducted to all patients enrolled in this study. Results:Nine (30%) patients had positive STEC test &nine (30%) patients had autoantibodies against CFH, and twelve (40%) patients with negative Shiga toxin test and no detectable autoantibodies against CFH.All patients presented with acute onset of intravascular hemolytic anemia, direct comb`s test was performed at onset and was negative in all patients. Almost all children had impaired Kidney function tests as evidenced by increased median urea&creatinine. Renal biopsy was indicted during the course of illness in 10 (33.3%) & Pathology of the studied renal biopsies was indicative of TMA in all specimens
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.M.Sc.2020.Ma.H (Browse shelf(Opens below)) Not for loan 01010110081316000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.M.Sc.2020.Ma.H (Browse shelf(Opens below)) 81316.CD Not for loan 01020110081316000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Background:There has been a dramatic acceleration in the understanding of the pathogenesis of primary thrombotic microangiopathy (TMA) syndromes. This will create opportunities for specific treatments and the availability of specific treatments has created the need for rapid and specific diagnoses. Objective:was to provide a clinical description of primary thrombotic microangiopathy syndromes in the pediatric age group, and to identify the underlying immunological disturbances in such group of diseases. Methods: This cross sectional analytical study was conducted on 30 children with clinical and laboratory features suggestive of TMA at Cairo University Children Hospital at the period from August 2019 to February 2020. Shiga toxin screening (STEC),complement assay, ADAMT13 antigen concentration, homocysteine, CBC, urea&creatinine, coagulation profile and total& direct bilirubin were conducted to all patients enrolled in this study. Results:Nine (30%) patients had positive STEC test &nine (30%) patients had autoantibodies against CFH, and twelve (40%) patients with negative Shiga toxin test and no detectable autoantibodies against CFH.All patients presented with acute onset of intravascular hemolytic anemia, direct comb`s test was performed at onset and was negative in all patients. Almost all children had impaired Kidney function tests as evidenced by increased median urea&creatinine. Renal biopsy was indicted during the course of illness in 10 (33.3%) & Pathology of the studied renal biopsies was indicative of TMA in all specimens

Issued also as CD

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