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Role oF OCT-A to detect possible retinal vascular complications of sofosbuvir (sovaldi) in patients with hepatitis C virus infection / Mohamed Saad Emam Ahmed ; Supervised Magda Salaheldin Abdelaziz Ahmed , Hany Elmekawey Elmekawey , Yomna Amr Abdelwahab

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohamed Saad Emam Ahmed , 2020Description: 113 P. : charts , facsimiles ; 25cmOther title:
  • دور اىشعة المقطعية الضوئية المتداخلة للأوعية الدموية فى اكتشاف مضاعفات شبكية العين الممكن حدوثها مع عقار السوفوسبوفير (سوفالدى) فى مرضى الالتهاب الكبدى الوبائى - سى [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Ophthalmology Summary: Purpose: The purpose of this study is to evaluate the value of optical coherence tomography angiography (OCT-A) for the of detection of any suspected retinal complications associated with use of combined therapy (Sofosbuvir "Sovaldi" and Daclatasvir "Daklinza") in Patients With Hepatitis C Virus Infection Design: prospective cohort study.Methods: During 3 months duration ( the treatment course duration) , Optical coherence tomography angiography (OCT-A) were imaged to 28 eyes of 28 patients with a documented diagnosis of chronic hepatitis C before and after receiving dual-therapy planning (Daclatasvir- Sofosbuvir ). Results: The results in this study revealed, statistically significant (p-value less than 0.05 %) reduction in the deep capillary plexuses density , and choriocapillaris flow area, and in FAZ flow density (FD ), statistically insignificant reduction in superficial capillary plexuses vessel density and thickness , statistically significant, with appearance of macular drusens and reduction in visual acuity and tear film. Conclusions: HCV Dual treatment (Sofosbuvir, Daclatasvir) may result in significant changes affecting retinal microvasculature and may cause eye dryness
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.24.M.Sc.2020.Mo.R (Browse shelf(Opens below)) Not for loan 01010110081346000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.24.M.Sc.2020.Mo.R (Browse shelf(Opens below)) 81346.CD Not for loan 01020110081346000
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Cai01.11.24.M.Sc.2020.Me.C Comparison of different methods of intraocular pressure measurements by Goldmann applanation tonometry, air puff tonometry and ocular response analyzer following intrastromal corneal ring segments implantation / Cai01.11.24.M.Sc.2020.Me.C Comparison of different methods of intraocular pressure measurements by Goldmann applanation tonometry, air puff tonometry and ocular response analyzer following intrastromal corneal ring segments implantation / Cai01.11.24.M.Sc.2020.Mo.R Role oF OCT-A to detect possible retinal vascular complications of sofosbuvir (sovaldi) in patients with hepatitis C virus infection / Cai01.11.24.M.Sc.2020.Mo.R Role oF OCT-A to detect possible retinal vascular complications of sofosbuvir (sovaldi) in patients with hepatitis C virus infection / Cai01.11.24.M.Sc.2020.Ra.E Evaluation of the influence of perioperative topical nepafenac on retinal vasculature Following uneventful phacoemulsification using optical coherence tomography Angiography : A comparative randomized study / Cai01.11.24.M.Sc.2020.Ra.E Evaluation of the influence of perioperative topical nepafenac on retinal vasculature Following uneventful phacoemulsification using optical coherence tomography Angiography : A comparative randomized study / Cai01.11.24.M.Sc.2020.Re.D Detecting macular changes by optical coherence tomography in cases of open globe injuries within two weeks of trauma /

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Ophthalmology

Purpose: The purpose of this study is to evaluate the value of optical coherence tomography angiography (OCT-A) for the of detection of any suspected retinal complications associated with use of combined therapy (Sofosbuvir "Sovaldi" and Daclatasvir "Daklinza") in Patients With Hepatitis C Virus Infection Design: prospective cohort study.Methods: During 3 months duration ( the treatment course duration) , Optical coherence tomography angiography (OCT-A) were imaged to 28 eyes of 28 patients with a documented diagnosis of chronic hepatitis C before and after receiving dual-therapy planning (Daclatasvir- Sofosbuvir ). Results: The results in this study revealed, statistically significant (p-value less than 0.05 %) reduction in the deep capillary plexuses density , and choriocapillaris flow area, and in FAZ flow density (FD ), statistically insignificant reduction in superficial capillary plexuses vessel density and thickness , statistically significant, with appearance of macular drusens and reduction in visual acuity and tear film. Conclusions: HCV Dual treatment (Sofosbuvir, Daclatasvir) may result in significant changes affecting retinal microvasculature and may cause eye dryness

Issued also as CD

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