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Formation of sensitive nanoparticles based on Alginate derivatives to be used as drug delivery systems / Yassmen Abdelsalam Elsayed Mohamed ; Supervised Riham Rashad Mohamed Ali , Soliman Mehawed Abdellatif Soliman

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Yassmen Abdelsalam Elsayed Mohamed , 2020Description: 80 P. : charts , facsimiles ; 25cmOther title:
  • تكوين جسيمات نانوية حساسة مبنية على مشتقات اللألجيىات لأستخدامها كأنظمه موصله للعقاقير [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry Summary: Sodium alginate was modified using grafting technique and by chemical modification. Firstly, Acrylonitrile was grafted onto sodium alginate to obtain amphiphilic copolymer SA-g-PAN. The kinetic parameters of grafting process included monomer concentration, initiator concentration, reaction temperature and time were studied. The grafting parameters such as the percent graft yield (% G), percent graft efficiency (% GE) and percent homopolymer (% H) were calculated and determined the optimum conditions for grafting process. The copolymer was characterized using FTIR spectroscopy, XRD and thermogravimetric analysis. Nanoparticles based on prepared SA-g-PAN were formed through nanoprecipitation technique and characterized by Transmission electron microscope (TEM) and then hydrophobic model was encapsulated Secondly, modification of sodium alginate has been done through cations-exchange between sodium ions and p-phenylenediamine hydrochloride salt. The modified alginate (PPD-SA) was characterized using FTIR spectroscopy, XRD and thermogravimetric analysis. Nanoparticles based on the modified alginate was formed via nanoprecipitation technique and cytotoxicity was tested
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.10.M.Sc.2020.Ya.F (Browse shelf(Opens below)) Not for loan 01010110081353000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.10.M.Sc.2020.Ya.F (Browse shelf(Opens below)) 81353.CD Not for loan 01020110081353000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry

Sodium alginate was modified using grafting technique and by chemical modification. Firstly, Acrylonitrile was grafted onto sodium alginate to obtain amphiphilic copolymer SA-g-PAN. The kinetic parameters of grafting process included monomer concentration, initiator concentration, reaction temperature and time were studied. The grafting parameters such as the percent graft yield (% G), percent graft efficiency (% GE) and percent homopolymer (% H) were calculated and determined the optimum conditions for grafting process. The copolymer was characterized using FTIR spectroscopy, XRD and thermogravimetric analysis. Nanoparticles based on prepared SA-g-PAN were formed through nanoprecipitation technique and characterized by Transmission electron microscope (TEM) and then hydrophobic model was encapsulated Secondly, modification of sodium alginate has been done through cations-exchange between sodium ions and p-phenylenediamine hydrochloride salt. The modified alginate (PPD-SA) was characterized using FTIR spectroscopy, XRD and thermogravimetric analysis. Nanoparticles based on the modified alginate was formed via nanoprecipitation technique and cytotoxicity was tested

Issued also as CD

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