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Multi-component reactions of cyclohexan-1,3-dione for the synthesis of thiophene, pyrazole and pyran derivatives with antitumor activities / Marwa Soliman Gamaan Salama ; Supervised Rafat M. Mohareb , Naglaa Y. Samy , Nadia Y. Megally Abdo

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Marwa Soliman Gamaan Salama , 2019Description: 198 P. : charts , facsimiles ; 25cmOther title:
  • تفاعلات متعددة المكونات من السيكلوهكسان- 3,1 -ثنائى الكيتون لتحضير مشتقات الثيوفين و البيرازول و البيوران ذات أنشطة مضادة للأورام [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry Summary: Cyclohexan-1,3-dione (1) which reacted with salicylaldehyde (2) and either malononitrile (3a) or ethyl cyanoacetate (3b) in ethanol containing a catalytic amount of triethylamine to give the 3,4,7,12b-tetrahydrochromeno[3,4-c]chromen-1-one derivatives 5a,b. The latter compounds underwent Gewald{u2019}s thiophene synthesis through the reaction with either malononitrile or ethyl cyanoacetate to give compounds 6a-d, respectively.The latter products underwent a series of heterocyclization reactions to yield pyran, pyridine, thiophene and pyrazole derivatives. The synthesized compounds were evaluated against the six cancer cell lines A549, HT-29, MKN-45, U87MG, and SMMC-7721 and H460 using the standard MTT assay in vitro, with foretinib as the positive control. Many compounds expressed high inhibitions
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.10.Ph.D.2019.Ma.M (Browse shelf(Opens below)) Not for loan 01010110081356000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.10.Ph.D.2019.Ma.M (Browse shelf(Opens below)) 81356.CD Not for loan 01020110081356000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry

Cyclohexan-1,3-dione (1) which reacted with salicylaldehyde (2) and either malononitrile (3a) or ethyl cyanoacetate (3b) in ethanol containing a catalytic amount of triethylamine to give the 3,4,7,12b-tetrahydrochromeno[3,4-c]chromen-1-one derivatives 5a,b. The latter compounds underwent Gewald{u2019}s thiophene synthesis through the reaction with either malononitrile or ethyl cyanoacetate to give compounds 6a-d, respectively.The latter products underwent a series of heterocyclization reactions to yield pyran, pyridine, thiophene and pyrazole derivatives. The synthesized compounds were evaluated against the six cancer cell lines A549, HT-29, MKN-45, U87MG, and SMMC-7721 and H460 using the standard MTT assay in vitro, with foretinib as the positive control. Many compounds expressed high inhibitions

Issued also as CD

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