Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology

Background:Vitiligo is a relatively common skin depigmenting disorder, of multifactorial etiology including genetic, immunologicaland oxidant-antioxidant imbalance.Nonsegmental vitiligo, the commonest form of vitiligo, is now postulated to be a systemic disease, rather than a mere dermatological disorder, having a strong association with several systemic and metabolic disturbances, including insulin resistance, dyslipidemia, atherosclerotic cardiovascular disease (CVD) and metabolic syndrome. However, contradicting data were also published, denoting that vitiligo patients tend to have lower cardiovascular risk than controls. Methods:In this hospital based, cross sectional, case-control study, 50 patients with non-segmental vitiligo and 50 age and sex matched controls were included. All study subjects were selected from non-smoking subjects, free from diabetes mellitus, hypertension and obesity. Serum lipid profile (including LDL-C, HDL-C, total cholesteroland triglycerides),in addition to serum oxidative stress biomarkers (hydrogen peroxide, malondialdehyde, nitric oxide and total antioxidant capacity) were measured. Carotid duplexwas performedwithestimation of common carotid intima media thickness (CCIMT) and assessment for atherosclerotic plaque presence and measurements

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