Trials for preparation of improved bivalent live and inactivated NDV (Clone 30) and infectious bronchitis virus vaccine / Walaa Abdelfatah Saad Metwally ; Supervised Ahmed Abdelghani Elsanousi , Basem Mohamed Abdelhamid Ahmed , Mohamed Abdelkhaleck Aly Abdelkhaleck

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Walaa Abdelfatah Saad Metwally

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TextLanguage: English Publication details: Cairo : Walaa Abdelfatah Saad Metwally , 2020Description: 163 P. : charts ; 25cmOther title:

محاولات لتحضير لقاح ثنائى محسن حى و مثبط لفيروس مرض النيوكاسل (كلون 30) و فيروس مرض الالتهاب الشعبى المعدى [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of veterinary Medicine - Department of Virology Summary: Aim: Vaccination of chickens with a clone-selected Lastoa strain of Newcastle disease virus and to develop a mucosal inactivated vaccine for Newcastle and infectious bronchitis viruses to protect against these viruses infections through mucosal immunity, Preparation of bivalent live and inactivated vaccines of clone 30 and Infectious bronchitis viruses and comparing it with it{u2019}s monovalent homologus vaccines and monovalent and bivalent lasota and Infectious bronchitis live and inactivated vaccines. Materials and Methods: In this study, we prepared two new formulations of bivalent vaccine, live and inactivated vaccine formulations for Newcastle ( clone30 , lasota) and infectious bronchitis virus strains. The prepared live vaccines were delivered via oral route in drinking water and the prepared inactivated vaccines were delivered via spray route and subcutaneous injection in specific pathogen-free chickensm,Cell-mediated and humeral immune response was measured as well as challenge trial was carried out. Results: Our results showed that the use of live clone30 vaccine giving almost the same protective level as Lasota strain live vaccine with minimal adverse clinical post vaccinal reactions as clinical respiratory disease which being happened usually in live Lasota vaccination, In addition to that, the bivalent vaccine gives the same results as the monovalent live prepared vaccine. Also, the use of bivalent inactivated vaccine giving a very good protective level as achieved by monovalent inactivated vaccines which saving the cost and load of multiple vaccination programs. Also, the use of polymer Montanide adjuvant revealed that it enhance the cell mediated immune response as indicated by lymphocyte blastogenesis assay

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Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.10.17.Ph.D.2020.Wa.T (Browse shelf(Opens below))		Not for loan		01010110081527000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.10.17.Ph.D.2020.Wa.T (Browse shelf(Opens below))	81527.CD	Not for loan		01020110081527000

Thesis (Ph.D.) - Cairo University - Faculty of veterinary Medicine - Department of Virology

Aim: Vaccination of chickens with a clone-selected Lastoa strain of Newcastle disease virus and to develop a mucosal inactivated vaccine for Newcastle and infectious bronchitis viruses to protect against these viruses infections through mucosal immunity, Preparation of bivalent live and inactivated vaccines of clone 30 and Infectious bronchitis viruses and comparing it with it{u2019}s monovalent homologus vaccines and monovalent and bivalent lasota and Infectious bronchitis live and inactivated vaccines. Materials and Methods: In this study, we prepared two new formulations of bivalent vaccine, live and inactivated vaccine formulations for Newcastle ( clone30 , lasota) and infectious bronchitis virus strains. The prepared live vaccines were delivered via oral route in drinking water and the prepared inactivated vaccines were delivered via spray route and subcutaneous injection in specific pathogen-free chickensm,Cell-mediated and humeral immune response was measured as well as challenge trial was carried out. Results: Our results showed that the use of live clone30 vaccine giving almost the same protective level as Lasota strain live vaccine with minimal adverse clinical post vaccinal reactions as clinical respiratory disease which being happened usually in live Lasota vaccination, In addition to that, the bivalent vaccine gives the same results as the monovalent live prepared vaccine. Also, the use of bivalent inactivated vaccine giving a very good protective level as achieved by monovalent inactivated vaccines which saving the cost and load of multiple vaccination programs. Also, the use of polymer Montanide adjuvant revealed that it enhance the cell mediated immune response as indicated by lymphocyte blastogenesis assay

Issued also as CD

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