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Assessment of certain long non-coding RNAs and mRNAs in Egyptian HCV Patients / Nourhan M. Elsamaloty ; Supervised Sherine M. Rizk , Maha M. Elsawalhi , Shohda A. Elmaraghy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Nourhan Mohamed Elsamaloty , 2020Description: 81 P . : charts , facsmilies ; 25cmOther title:
  • تقييم بعض الاحماض النووية الريبوزية الطويلة غير المشفرة و الاحماض النووية الريبوزية المرسلة فى المرضى المصريين المصابين بفيروس الإلتهاب الكبدى نوع سى [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry Summary: Viral hepatitis is the seventh leading cause of mortality worldwide. Hepatitis C virus comprises almost half of this mortality, ultimately leading to cirrhosis and hepatocellular carcinoma (HCC). In 2008, the predominance of HCV infection in Egypt was the most noteworthy in the world, near 15% of the populace were seropositive, and approximately 90% of patients were infected with genotype 4 (GT4). In 2015, the National Demographic Health Survey proved a noticeable drop in HCV burden to 6.3% among the population.Egypt launched one of the largest treatment programmes for controlling viral hepatitis with direct-acting antiviral (DAAs)-based regimens that aim to treat above 250,000 chronically infected individuals per year. Sofosbuvir combination-based regimens were designed as a promising regimen for the treatment of HCV GT4 patients. HCV infection is a complex multifactorial process that involves multiple viral and host interactions. Besides, the high mutation rate of HCV that enables the virus to generate escape mutants resistant to treatment, emphasizing the need for a proper understanding of the pathogenesis of HCV infection, and various research efforts should be oriented to develop novel diagnostic and prognostic molecular tools
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.Ph.D.2020.No.A (Browse shelf(Opens below)) Not for loan 01010110081510000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.Ph.D.2020.No.A (Browse shelf(Opens below)) 81510.CD Not for loan 01020110081510000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry

Viral hepatitis is the seventh leading cause of mortality worldwide. Hepatitis C virus comprises almost half of this mortality, ultimately leading to cirrhosis and hepatocellular carcinoma (HCC). In 2008, the predominance of HCV infection in Egypt was the most noteworthy in the world, near 15% of the populace were seropositive, and approximately 90% of patients were infected with genotype 4 (GT4). In 2015, the National Demographic Health Survey proved a noticeable drop in HCV burden to 6.3% among the population.Egypt launched one of the largest treatment programmes for controlling viral hepatitis with direct-acting antiviral (DAAs)-based regimens that aim to treat above 250,000 chronically infected individuals per year. Sofosbuvir combination-based regimens were designed as a promising regimen for the treatment of HCV GT4 patients. HCV infection is a complex multifactorial process that involves multiple viral and host interactions. Besides, the high mutation rate of HCV that enables the virus to generate escape mutants resistant to treatment, emphasizing the need for a proper understanding of the pathogenesis of HCV infection, and various research efforts should be oriented to develop novel diagnostic and prognostic molecular tools

Issued also as CD

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