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Pharmaceutical study on antifungal drug / Mohammed Yousef Salem Abary ; Supervised Mohamed Ahmed Elnabarawi , Randa Tag Abdelrehem , Hala Mohammed Elmofty

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohammed Yousef Salem Abary , 2020Description: 292 P . : charts , facsmilies , photographs ; 25cmOther title:
  • درا{uئإآ٣}{uئإ٩٤} {uئإآآ}{uئآئئ}{uئإءء}{uئإؤئ}{uئآئئ}{uئإ٩٤} {uئإأآ}{uئإإ٠}{uئإئ٠} {uئإأآ}{uئإؤ٨}{uئإ٨إ}ر {uئإإ٣}{uئإأ٠}{uئإ٨إ}د {uئإؤئ}{uئإإ٠}{uئإؤ٤}{uئإأ٤}{uئإءإ}{uئآئإ}{uئإ٨إ}ت [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: The use of niosomal carrier system will improve natamycin (NAT) ocular bioavailability. So this study was aimed to develop dual-purpose NAT-loaded niosomes in ketorolac tromethamine (KT) gels ocular drug delivery system to improve the clinical efficacy of natamycin through enhancing its penetration through corneal tissue and reducing inflammation associated with fungal keratitis (FK). Niosomes were prepared using the reverse-phase evaporation technique. In vitro experimental and in vivo clinical evaluations for these formulations were done for assessment of their safety and efficacy for treatment of Candida albicans and Aspergillus flavus Keratitis in Rabbits. In vitro release study was carried out by dialysis method. In vivo microbiological and histopathological studies were performed on albino rabbits.NAT niosomes exhibited high entrapment efficiency percentage (E.E%) were ranged between 90.99% (F3) and 97.64% (F8) and particle size diameter ranging from 181.75 ± 0.64 to 498.95 ± 0.64 nm, with negatively charged zeta potential (ZP) ranging between -28.80 mV and -73.75 mV.NAT niosomal dispersion exhibited prolonged in vitro drug % release efficiency were ranged between (19.86% (F15) to 61.1% (F6) over 24h)
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.Ph.D.2020.Mo.P (Browse shelf(Opens below)) Not for loan 01010110081558000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.Ph.D.2020.Mo.P (Browse shelf(Opens below)) 81558.CD Not for loan 01020110081558000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

The use of niosomal carrier system will improve natamycin (NAT) ocular bioavailability. So this study was aimed to develop dual-purpose NAT-loaded niosomes in ketorolac tromethamine (KT) gels ocular drug delivery system to improve the clinical efficacy of natamycin through enhancing its penetration through corneal tissue and reducing inflammation associated with fungal keratitis (FK). Niosomes were prepared using the reverse-phase evaporation technique. In vitro experimental and in vivo clinical evaluations for these formulations were done for assessment of their safety and efficacy for treatment of Candida albicans and Aspergillus flavus Keratitis in Rabbits. In vitro release study was carried out by dialysis method. In vivo microbiological and histopathological studies were performed on albino rabbits.NAT niosomes exhibited high entrapment efficiency percentage (E.E%) were ranged between 90.99% (F3) and 97.64% (F8) and particle size diameter ranging from 181.75 ± 0.64 to 498.95 ± 0.64 nm, with negatively charged zeta potential (ZP) ranging between -28.80 mV and -73.75 mV.NAT niosomal dispersion exhibited prolonged in vitro drug % release efficiency were ranged between (19.86% (F15) to 61.1% (F6) over 24h)

Issued also as CD

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