Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Introduction;2Suspected sepsis3 is one of the most frequently challenging diagnosisin neonates, the clinical signs of infection are not specific and late. Blood culture - the golden standard in neonatal sepsis diagnosis {u2013} provides late information.Aim of work ;Evaluation of Rodwell score efficiency and CD64 and CD11b expression in cases with culture proven sepsis. Patients and methods;107 patients with culture proven sepsis were examined for monocytic and neutrophilic CD11b and CD64 expressions analyzed by flowcytometry, and their CBC was analyzed and Rodwell score was calculated.Results; CD64 on both monocytes and neutrophils weresignificantly higher among patients with culture proven sepsis than that in control group with (P< 0.001) for both with sensitivity of 94.9% and 76.2%, and specificity of 59% and 83% respectively., while there was no significant different for CD11b on both monocytes and neutrophils between cases and control groups.We also found that Rodwell score was significantly higher in cases than the control group with (P<0.001) with sensitivity of 87.85% and specificity of 94%.Conclusion; that HSS is a simple screening test for early diagnosis of neonatal sepsis. It may aid the clinicians in identifying sepsis and to institute proper anti-biotic therapy. Unnecessary exposure of infants to antibiotic therapy can thus be avoided

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