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Process development of nano-aluminum hydroxide adjuvanted rift valley fever virus vaccine / Shourok Essam Aly Abdelhady ; Supervised Mohamed A. Shalaby , Ausama A. Yousif , Karim Eldin Zaki

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Shourok Essam Aly Abdelhady , 2020Description: 96 P. : charts , facsimiles ; 25cmOther title:
  • تطوير العمليات لإنتاج لقاح لفيروس حمى الوادي المتصدع مُساعد بمادة هدروكسيد الألومنيوم متناهى الصغر [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Virology Summary: In this study the aluminum hydroxide adjuvant gel used widely in a lot of human and animal vaccines and currently solely used as an adjuvant in the locally produced inactivated Rift Valley Fever vaccine was treated by ultrasonication in the presence of trehalose for dispersion of its particles. The dispersed aluminum hydroxide adjuvant was extensively studied where various physical characters were determined. The particle size of aluminum hydroxide was significantly reduced as the aggregates size ranging from 1-20 æm. As a result of dispersion, the TEM image of vaccine showed a change of the content from nonuniform and large aggregates of aluminum hydroxide with Rift Valley fever inactivated virus diffused in it to uniform particles with aluminum hydroxide adsorbed on virus surface and having a diameter of 300 nm. The vaccine with dispersed aluminum hydroxide was used in immunizing mice and showed superiority in immunogenicity when compared to the conventional vaccine
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.17.M.Sc.2020.Sh.P (Browse shelf(Opens below)) Not for loan 01010110081694000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.17.M.Sc.2020.Sh.P (Browse shelf(Opens below)) 81694.CD Not for loan 01020110081694000

Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Virology

In this study the aluminum hydroxide adjuvant gel used widely in a lot of human and animal vaccines and currently solely used as an adjuvant in the locally produced inactivated Rift Valley Fever vaccine was treated by ultrasonication in the presence of trehalose for dispersion of its particles. The dispersed aluminum hydroxide adjuvant was extensively studied where various physical characters were determined. The particle size of aluminum hydroxide was significantly reduced as the aggregates size ranging from 1-20 æm. As a result of dispersion, the TEM image of vaccine showed a change of the content from nonuniform and large aggregates of aluminum hydroxide with Rift Valley fever inactivated virus diffused in it to uniform particles with aluminum hydroxide adsorbed on virus surface and having a diameter of 300 nm. The vaccine with dispersed aluminum hydroxide was used in immunizing mice and showed superiority in immunogenicity when compared to the conventional vaccine

Issued also as CD

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