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Development and validation of analytical methods for determination of dome hormones / Reham Mohamed Arafa Abdelhammed ; Supervised Sawsan Mohamed Amer, Samah Sayed Abbas , Ali Mohamed Yehia

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Reham Mohamed Arafa Abdelhammed , 2020Description: 195 P. : charts , facimiles ; 25cmOther title:
  • تطوير وصلاحية طرق تحليلية لتقدير بعض الهرمونات [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry Summary: Different analytical techniques, namely chromatography, Capillary electrophoresis, spectrophotometry and chemometry were adopted for determination of some hormones; namely, Estradiol valerate (EST), Norethisterone acetate (NOR) in presence of other related compounds (estradiol, estrone and estriol) and Epinephrine (EPI) in presence of norepinephrine and their enantiomeric impurities. The aim of this work was to develop different analytical methods which are characterized by simplicity, accuracy and appropriate degree of sensitivity for the analysis of the aforementioned drugs in their powdered form, laboratory prepared mixtures and in their pharmaceutical dosage forms. One of the latest used greenness evaluation tools for analytical techniques is the analytical eco-scale, which is a semi-quantitative tool to evaluate and compare analytical methods based on their conformity with green chemistry principles. All of the presented methods have been validated according to the ICH- guidelines.The proposed methods can be used for quality control analysis of the studied drugs either in bulk powder or pharmaceutical formulation. This thesis contains three parts in addition to references, arabic and English summaries; Part I; General introduction of hormones. Part II; Simultaneous determination of Estradiol valerate and norethisterone acetate along with estradiol, estrone and estriol Part III; Determination of L-Epinephrine in presence of L-Norepinephrine and their Enantiomeric Impurities
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.03.Ph.D.2020.Re.D (Browse shelf(Opens below)) Not for loan 01010110081739000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.03.Ph.D.2020.Re.D (Browse shelf(Opens below)) 81739.CD Not for loan 01020110081739000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry

Different analytical techniques, namely chromatography, Capillary electrophoresis, spectrophotometry and chemometry were adopted for determination of some hormones; namely, Estradiol valerate (EST), Norethisterone acetate (NOR) in presence of other related compounds (estradiol, estrone and estriol) and Epinephrine (EPI) in presence of norepinephrine and their enantiomeric impurities. The aim of this work was to develop different analytical methods which are characterized by simplicity, accuracy and appropriate degree of sensitivity for the analysis of the aforementioned drugs in their powdered form, laboratory prepared mixtures and in their pharmaceutical dosage forms. One of the latest used greenness evaluation tools for analytical techniques is the analytical eco-scale, which is a semi-quantitative tool to evaluate and compare analytical methods based on their conformity with green chemistry principles. All of the presented methods have been validated according to the ICH- guidelines.The proposed methods can be used for quality control analysis of the studied drugs either in bulk powder or pharmaceutical formulation. This thesis contains three parts in addition to references, arabic and English summaries; Part I; General introduction of hormones. Part II; Simultaneous determination of Estradiol valerate and norethisterone acetate along with estradiol, estrone and estriol Part III; Determination of L-Epinephrine in presence of L-Norepinephrine and their Enantiomeric Impurities

Issued also as CD

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