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Imaging features of CNS complications in hematopoietic stem cell transplanted pediatric oncology patients / Samar Ahmed Mohamed Aly ; Supervised Iman Mohamed Zaky , Ayda Aly Youssef , Amr Abdalla Salem

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Samar Ahmed Mohamed Aly , 2020Description: 183 P. : charts , facimiles ; 25cmOther title:
  • صفات التصو{u٠٦أأ}ر لمضاعفات الجھاز العصبى المركزى فى س{u٠٦أأ}اق زرع الخلا{u٠٦أأ}ا الجذع{u٠٦أأ}ة المكونة للدم فى مرضى أورام الأطفال [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Oncology (Radiology) Summary: Hematopoietic stem cell transplant (HSCT) has been increasingly used in the last few decades, with improved success in offering a cure.CNS complications are an important contributor to morbidity & mortality in HSCT patients. Our study illustrates that CNS complications, with a day 100 and a 5-year incidence of 5.3% and 12.5%, respectively, is a significant clinical problem in post- HSCT patients. Nearly 41 % of the post-HSCT CNS complications occurred within 100 days after HSCT. A total of 9 patients (13% of total patients with CNS complications) had a double incidence of CNS imaging detected complications so, close monitoring is required for patients with those complications. The most commonly observed CNS complication in our series was CNS disease recurrence detected in 27/77 incidents (35%), followed by PRES detected in 17/77 incidents (22%). PRES was more common at <30 days post HSCT, while neurotoxicity, hemorrhage, recurrence, atrophy and infection were more common at the >100 days post-HSCT transplant period
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.06.Ph.D.2020.Sa.I (Browse shelf(Opens below)) Not for loan 01010110081849000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.06.Ph.D.2020.Sa.I (Browse shelf(Opens below)) 81849.CD Not for loan 01020110081849000

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Oncology (Radiology)

Hematopoietic stem cell transplant (HSCT) has been increasingly used in the last few decades, with improved success in offering a cure.CNS complications are an important contributor to morbidity & mortality in HSCT patients. Our study illustrates that CNS complications, with a day 100 and a 5-year incidence of 5.3% and 12.5%, respectively, is a significant clinical problem in post- HSCT patients. Nearly 41 % of the post-HSCT CNS complications occurred within 100 days after HSCT. A total of 9 patients (13% of total patients with CNS complications) had a double incidence of CNS imaging detected complications so, close monitoring is required for patients with those complications. The most commonly observed CNS complication in our series was CNS disease recurrence detected in 27/77 incidents (35%), followed by PRES detected in 17/77 incidents (22%). PRES was more common at <30 days post HSCT, while neurotoxicity, hemorrhage, recurrence, atrophy and infection were more common at the >100 days post-HSCT transplant period

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