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Ultrastructural & parasitological assessment of the effect of bee venom & mefloquine on molecularly subtyped isolated blastocystis hominis / Mai Abdelwahab Mohammad Moubarak ; Supervised Sayeda Mohammad Aufy , Fatem Ramzy Gerges , Salwa Morsy Huessain Morsy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mai Abdelwahab Mohammad Moubarak , 2020Description: 224 P . : charts , facsmilies ; 25cmOther title:
  • تقييم التركيب الدقيق و التقييم الطفيلى لتأثير سم العسل و المفلوكين على التصنيف الجزيئى الفرعى للبلاستوسيستيس هومينيس المعزولة [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Parasitology Summary: Blastocystis is a protozoan parasite that inhabits the human intestinal tract. Various epidemiological surveys have recorded 50-60% prevalence in developing countries. Nitazoxanide is a commonly used drug in treatment of blastocystis infection especially in metronidazole treatment failure. However,undesirable side effects and treatment failures were reported. To investigate the effect of bee venom and mefloquine against isolated Blastocystis spp. in comparison to nitazoxanide , fresh stools samples positive for this parasite were processed for in vitro cultivation using Jones' media.Three criteria were used to test the drug{u2019}s efficacy, Living cell count (LCC), Living cell rate (LCR) and ultra-structure changes as seen by transmission electron microscope (TEM). Molecular identification of the DNA of the organism, found in the chosen positively infected stool sample used for our study ,was done before adding the drugs. All the tested drugs (with all the used concentrations) showed a significant reduction in both LCC and LCR with p value< 0.001 and significant ultra-structural changes as seen by TEM. Bee venom & Mefloquine are promising new therapeutic agents against Blastocystis spp. especially bee venom as it is a natural compound with less side effects
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.26.M.Sc.2020.Ma.U (Browse shelf(Opens below)) Not for loan 01010110081830000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.26.M.Sc.2020.Ma.U (Browse shelf(Opens below)) 81830.CD Not for loan 01020110081830000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Parasitology

Blastocystis is a protozoan parasite that inhabits the human intestinal tract. Various epidemiological surveys have recorded 50-60% prevalence in developing countries. Nitazoxanide is a commonly used drug in treatment of blastocystis infection especially in metronidazole treatment failure. However,undesirable side effects and treatment failures were reported. To investigate the effect of bee venom and mefloquine against isolated Blastocystis spp. in comparison to nitazoxanide , fresh stools samples positive for this parasite were processed for in vitro cultivation using Jones' media.Three criteria were used to test the drug{u2019}s efficacy, Living cell count (LCC), Living cell rate (LCR) and ultra-structure changes as seen by transmission electron microscope (TEM). Molecular identification of the DNA of the organism, found in the chosen positively infected stool sample used for our study ,was done before adding the drugs. All the tested drugs (with all the used concentrations) showed a significant reduction in both LCC and LCR with p value< 0.001 and significant ultra-structural changes as seen by TEM. Bee venom & Mefloquine are promising new therapeutic agents against Blastocystis spp. especially bee venom as it is a natural compound with less side effects

Issued also as CD

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