Formulation and evaluation of biodegradable carriers for an antispasmodic drug / Alaa Ibrahim Mohamed Ali ; Supervised Mohamed Aly Kassem , Khaled Fathy Elshaboury

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Oral dosage form is the most common and widely used route of administration, that{u2019}s mainly because; it is a simple, economical (solid oral dosage forms do not require sterile conditions),easy route of ingestion, flexible (suits several types of drug candidates), noninvasive (administration with pain avoidance), and most important it achieves both patient{u2019}s compliance and convenience. The large surface area of the gastrointestinal tract (300-400m2) is formed mainly of absorptive villi that is covered by enterocytes, goblet cells, and interspersed by follicle associated epithelium. The high transcytotic capacity of M cells covering these lymphoid regions (Peyer{u2019}s patches) increased their significance for drug delivery. Researchers are under constant pressure to find new methods for incorporating different technologies in oral dosage forms, even small enhancements in the technology of drug delivery can produce substantial enhancement in drug bioavailability and increase patient compliance. Now the majority of research projects are made to convert solid oral formulations into controlled dosage forms. The newly produced controlled release dosage forms are capable of achieving both sustained and controlled release. Polymers are the main component in producing controlled release dosage forms, due to their unique characteristics such as swellability, bioerosion and biodegradation in body fluids. The main purpose of controlled release dosage forms is to maintain the drug concentration in the body.Treatments of chronic diseases are the most potential drug candidates to be formulated as controlled release dosage forms

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