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Central vascular function and relaxibility in beta-thalassemia major patients vs. sickle cell anemia patients by abdominal aorta and aortic root speckle tracking echocardiography / Marina George Fahmy Asaad ; Supervised Hala Mounir Agha , Gehan Hussein Ahmed , Rasha Abdelraouf Abdelaziz

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Marina George Fahmy Asaad , 2020Description: 190 P. : charts , facsimiles ; 25cmOther title:
  • معرفة تأثير مرض انيميا البحر المتوسط والانيميا المنجلية على الاوعية الدموية الرئيسية بواسطة الموجات الصوتية ذات خاصية تتبع النقطة [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics Summary: Background : Ý-Thalassemia major (TM) and sickle cell disease (SCD) are inherited hemoglobin disorders resulting in chronic hemolytic anemia. Cardiovascular involvement is an important cause of morbidity and mortality in these groups of patients.The narrow border is between overt myocardial dysfunction and clinically silent left ventricular (LV) and / or right ventricular (RV) dysfunction in those patients.3 D Speckle tracking echocardiography (3D STE) is a novel method for detection of subclinical myocardial involvement. We aimed to assess LV and RV strain using 3 D speckle tracking echocardiography correlating them with aortic root stiffness parameter measured by speckle tracking and serum LDH. Methodology : Thirty SCD and thirty Ý TM patients, age range 4-18 years, were compared to 30 healthy age and sex matched control group. Cases were subjected to clinical examination, laboratory measurement of hemoglobin level, serum ferritin and LDH. Transthoracic color Doppler echocardiography, 3D STE, tissue Doppler echocardiography and aortic speckle tracking were performed. Results: significant reduction in global longitudinal strain (GLS), global circumferential strain (GCS) and global area strain (GAS) in SCD and TM than control (P value <0.001) there was significantly lower aortic speckle tracking in patients with TM and SCD than control (P value< 0.001). LDH was significantly higher in SCD than both TM and control and it correlated significantly positive with mitral inflow E, (p value:0.022 and 0.072. r: 0.416 and -0.333 respectively) lateral E/E{u2019} (p value.<0.001and 0.818. r. 0.618 and -0. 044.respectively) and septal E/E{u2019} (p value 0.007 and 0.753& r value 0.485 and -0.060 respectively) in SCD but not TM and significant negative correlation between LDH and aortic root speckle tracking (value 0.681& r. -0.078.)
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.M.Sc.2020.Ma.C (Browse shelf(Opens below)) Not for loan 01010110081889000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.M.Sc.2020.Ma.C (Browse shelf(Opens below)) 81889.CD Not for loan 01020110081889000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Background : Ý-Thalassemia major (TM) and sickle cell disease (SCD) are inherited hemoglobin disorders resulting in chronic hemolytic anemia. Cardiovascular involvement is an important cause of morbidity and mortality in these groups of patients.The narrow border is between overt myocardial dysfunction and clinically silent left ventricular (LV) and / or right ventricular (RV) dysfunction in those patients.3 D Speckle tracking echocardiography (3D STE) is a novel method for detection of subclinical myocardial involvement. We aimed to assess LV and RV strain using 3 D speckle tracking echocardiography correlating them with aortic root stiffness parameter measured by speckle tracking and serum LDH. Methodology : Thirty SCD and thirty Ý TM patients, age range 4-18 years, were compared to 30 healthy age and sex matched control group. Cases were subjected to clinical examination, laboratory measurement of hemoglobin level, serum ferritin and LDH. Transthoracic color Doppler echocardiography, 3D STE, tissue Doppler echocardiography and aortic speckle tracking were performed. Results: significant reduction in global longitudinal strain (GLS), global circumferential strain (GCS) and global area strain (GAS) in SCD and TM than control (P value <0.001) there was significantly lower aortic speckle tracking in patients with TM and SCD than control (P value< 0.001). LDH was significantly higher in SCD than both TM and control and it correlated significantly positive with mitral inflow E, (p value:0.022 and 0.072. r: 0.416 and -0.333 respectively) lateral E/E{u2019} (p value.<0.001and 0.818. r. 0.618 and -0. 044.respectively) and septal E/E{u2019} (p value 0.007 and 0.753& r value 0.485 and -0.060 respectively) in SCD but not TM and significant negative correlation between LDH and aortic root speckle tracking (value 0.681& r. -0.078.)

Issued also as CD

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